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Recruiting Phase 2, Phase 3 NCT06427707
The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries.
Trial Parameters
Condition Intraoperative Bleeding
Sponsor Ain Shams University
Study Type INTERVENTIONAL
Phase Phase 2, Phase 3
Enrollment 90
Sex ALL
Min Age 18 Years
Max Age 60 Years
Start Date 2024-06-15
Completion 2024-10-31
Interventions
Intravenous Infusion of propofol, lidocaine, Magnesium sulfateIntravenous infusion of ketamine, lidocaine, Magnesium sulfateIntravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate
Brief Summary
Nasal surgeries are common day case procedures. Although surgical complications are rare, bleeding decreases surgical field visibility and may cause vascular, orbital or intracranial complications in addition to failure of procedure. So, it is crucial to maintain hypotensive anaesthesia to optimize the surgical field.
Eligibility Criteria
Inclusion Criteria: * ASA I-II, * scheduled for elective nasal surgery Exclusion Criteria: * Patients with uncontrolled hypertension. * Patients with cardiac disease. * Patients with renal, hepatic or cerebral insufficiency. * Patients with coagulopathy or receiving drugs influencing blood coagulation. * Anaemia, haemoglobinopathies or polycythemia. * Pregnancy. * Patients with known sensitivity to any of the study drug.