NCT06746805 The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise
| NCT ID | NCT06746805 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Maastricht University Medical Center |
| Condition | Exercise Metabolism |
| Study Type | INTERVENTIONAL |
| Enrollment | 27 participants |
| Start Date | 2024-03-04 |
| Primary Completion | 2025-09-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 27 participants in total. It began in 2024-03-04 with a primary completion date of 2025-09-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.
Eligibility Criteria
Inclusion Criteria: * 18-50 years of age * Trained cyclist/triathlete (VO2peak \> 55 ml/kg/min for males and \>48 ml/mg/min for females) * Healthy as per medical history and investigator's/physician's judgement * Having given written informed consent Exclusion Criteria: * Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteroids) * Smoking * Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus) * Diagnosed musculoskeletal disorders * Adhering to a carbohydrate restrictive diet * Participation in another study at the same time * Blood donation in the 2 months before the first experimental trial * Plasma donation in the 2 weeks before the first experimental trial * Males: VO2peak \<55 ml/min/kg body mass * Females: VO2peak \<48 ml/min/kg body mass * Females: pregnancy
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06746805 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 50 Years, studying Exercise Metabolism. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06746805 currently recruiting?
Yes, NCT06746805 is actively recruiting participants. Contact the research team at l.vanloon@maastrichtuniversity.nl for enrollment information.
Where is the NCT06746805 trial being conducted?
This trial is being conducted at Maastricht, Netherlands.
Who is sponsoring the NCT06746805 clinical trial?
NCT06746805 is sponsored by Maastricht University Medical Center. The trial plans to enroll 27 participants.