| NCT ID | NCT07217379 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | University of North Carolina, Chapel Hill |
| Condition | HIV (Human Immunodeficiency Virus) |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2025-10-02 |
| Primary Completion | 2026-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 24 participants in total. It began in 2025-10-02 with a primary completion date of 2026-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This research study aims to find out how safe and well tolerated the experimental study drugs are when given to persons with HIV (PWH) taking antiretroviral therapy (ART). The study treatments are MGD014 and MGD020, which are two antibodies developed specifically for HIV, and Vorinostat, an oral medication to help expose HIV in cells to the antibodies. The study will measure the impact of study treatment on non-active HIV in cells, and how long MGD014 and MGD020 stay in the body after they are given. In this study, participants will be randomly assigned to one of three groups. All participants receive MGD014 and MGD020, given sequentially as infusions through an IV for 4 doses. Participants in one group (group A) receive only MGD014 and MGD020. Participants in another group (group B) will stop taking their ART therapy for up to 8 weeks (a temporary treatment interruption (TTI)) while receiving MGD014 and MGD020. Participants in the third group (group C) receive Vorinostat in addition to MGD014 and MGD020. Total time of participation is about 8 months and involves 13 or 18 visits, depending on group assignment.
Eligibility Criteria
Inclusion Criteria: 1. HIV infection initially documented by at least one of the following at any time prior to study entry: * any licensed rapid HIV test * HIV antibody test * HIV Ag/Ab assay …and documented confirmation by at least one of the following at any time prior to study entry: * licensed Western blot of HIV ½ antibody differentiation immunoassay * a second antibody test by a method other than the initial rapid HIV and/or HIV antibody assay * HIV-1 antigen, plasma HIV-1 RNA viral assay. 2. Ages ≥ 18 to ≤ 65 years old 3. Able and willing to give written informed consent. 4. Able and willing to stay in contact with site during the duration of the trial 5. Able and willing to provide adequate locator information. 6. Able and willing to comply with all study requirements through duration of the trial. 7. Continuous ART for a minimum of 24 months prior to screening, defined as not missing more than 9 consecutive days in the last 3 months prior to screening. 8. No change in any ART medication in the 30 days prior to screening. 9. Permitted ART regimens include: • At least 3 ART agents (not counting ritonavir or cobicistat as one of the agents if less than a 200 mg total daily dose). One of the agents must include an integrase inhibitor, NNRTI (Non-Nucleoside Reverse Transcriptase Inhibitors), or a boosted-PI (protease inhibitor). OR • Two (2) ART agents in which one of the agents is either a boosted protease inhibitor or an integrase inhibitor. Note: Other potent fully suppressive antiretroviral combinations will be considered on a case-by-case basis. 10. Participants must be determined to have an alternative ART regimen that can be constructed to assure availability of an effective option if assigned to Arm B and TTI leads to selection of virus resistant to the current regimen. 11. Ability and willingness of participant to continue ART throughout the study or temporarily discontinue ART for up to 8 weeks (for Arm B) under closely monitored supervision. 12. Plasma HIV-1 RNA \<50 copies/mL at 2 time points in the 24 months prior to screening and never ≥50 copies/mL on 2 consecutive time points in the last 24 months. 13. No HIV RNA ≥200 copies/mL in the 6 months prior to screening. 14. CD4 cell count ≥ 400 cells/mm3 performed at screening. 15. At US sites, Hepatitis C (HCV) antibody negative result at screening or, if the participant is HCV antibody positive, a negative HCV RNA at screening; at Kenyan sites, participants must be HCV antibody negative at screening. 16. Hepatitis B surface antigen (HBsAg) negative at screening. 17. Women of child-bearing potential must have a negative serum pregnancy test with a sensitivity of at least 25 milli-international unit (mIU) per milliliter at screening Note: Women of child-bearing potential is defined as women who have not been post-menopausal for at least 24 consecutive months, i.e., who have had menses within the preceding 24 months, or women who have not undergone surgical sterilization, specifically hysterectomy and/or bilateral oophorectomy or bilateral salpingectomy 18. For participants with partners who do not have HIV or HIV status unknown, willingness to abstain from sexual intercourse, use a condom, and/or advise partner(s) to use pre-exposure prophylaxis (PrEP) consistently during the study TTI and until plasma HIV-1 RNA is \<200 copies/mL if assigned to Arm B. 19. All participants must agree not to participate in a conception process (e.g., active attempt to become pregnant or to impregnate, sperm donation, in vitro fertilization, egg donation) while on study and for 6 months after their last investigational product (IP) intervention. 20. All men and women participating in sexual activity that could lead to pregnancy must agree to consistently use at least one of the following forms of birth control for at least 21 days prior to Visit 3 (Day 0) and for 6 months after their last IP intervention. * Condoms (internal or external) with or without a spermicidal agent * Diaphragm or cervical cap with spermicide * Intrauterine device (IUD) * Tubal ligation * Hormone-based contraceptive 21. Agrees not to enroll on another study of an investigational agent during the study period, defined as any unlicensed investigational drug not yet approved for use in humans. 22. Willingness to defer live vaccinations (e.g., varicella, measles, mumps, rubella (MMR), yellow fever, oral polio, Mpox) from 30 days prior to enrollment through week 16. 23. Willingness to defer routine vaccination, including influenza, from 14 days prior to enrollment through Week 16 of the study. Note: Individuals who require vaccination will delay enrollment until 14 days after vaccination. 24. Agrees to refrain from blood donation during the course of the study. 25. Participants with Type 2 diabetes must have a hemoglobin A1C \<8 or a fasting glucose ≤ 125 mg/dL; mmol/L at screening. 26. Adequate organ function as indicated by the laboratory values in Table 7 of the protocol. Exclusion Criteria: 1. Women who are pregnant or breastfeeding. 2. Untreated syphilis infection defined as a positive rapid plasma reagin (RPR) without clear documentation of treatment. 3. Current treatment for HCV or HCV treatment within 6 months prior to enrollment. 4. Received any infusion blood product or hematopoetic growth factors within 3 months prior to enrollment. 5. Started ART within 90 days of diagnosis with acute HIV-1 infection. 6. Use of antiretrovirals that might interfere with MGD014 or MGD020: maraviroc (Selzentry), enfuvirtide (T-20), fostemsavir (Rubokia), Ibalizumab (Trogarzo). 7. Use of long-acting antiretroviral regimens given potential TTI. 8. Use of any of the following agents within 90 days prior to enrollment: immunomodulatory, cytokine, or growth stimulating factors such as systemic cytotoxic chemotherapy or immune globulin, interferons, coumadin, warfarin, or other Coumadin derivative anticoagulants. 9. Intent to use immunomodulatory treatment during the study. 10. Use of systemic corticosteroids within 30 days prior to enrollment, or anticipated need for periodic use of systemic corticosteroids during the study. Note: Participants receiving stable physiologic doses of glucocorticoids, defined as the equivalent of prednisone ≤10 mg/day, are not excluded. Participants receiving inhaled, intranasal, topical, intermittent intra-articular corticosteroids, or topical imiquimod are not excluded. Concomitant use of oral/systemic /intra-articular/inhaled/intranasal corticosteroids is prohibited for participants receiving ritonavir or cobicistat. 11. Use of the following medications that carry risk of torsade des pointes: amiodarone, arsenic trioxide, astemizole, bepridil, chloroquine, chlorpromazine, cisapride, clarithromycin, disopyramide, dofetilide, domperidone, droperidol, erythromycin, halofantrine, haloperidol, ibutilide, levomethadyl, mesoridazine, methadone, pentamidine, pimozide, probucol, procainamide, quinidine, sotalol, sparfloxacin, terfenadine, thioridazine. 12. Receipt of compounds with histone deacetylase (HDAC) inhibitor-like activity, such as valproic acid within the last 30 days. Potential participants may enroll after a 30-day washout period. 13. Use of any other investigational treatment within 6 months prior to enrollment, with the exception of Phase 2 or higher studies of antiretroviral agents. Note: Co-enrollment with other studies under an investigational new drug (IND) using an FDA approved medication that is not otherwise listed as prohibited will be considered on a case-by-case basis. 14. Any serious illness requiring systemic treatment or hospitalization, the participant must either complete therapy or be clinically stable on therapy, in the opinion of the site investigator, for at least 90 days prior to enrollment. 15. Any medical, psychiatric, substance abuse, occupational or other condition that, in the judgment of the investigator, would interfere with, or serve as a contraindication to, protocol adherence or assessment of safety. 16. History of malignancy within the last 3 years. Note: History of non-melanoma skin cancer (e.g., basal cell carcinoma or squamous cell skin cancer) is not exclusionary with documented resolution per topical treatment or complete resection determined by a dermatologist at least 3 months prior to enrollment. 17. Immune deficiency other than that caused by HIV infection. 18. Blood pressure consistently \>150 mm Hg systolic and \>100 mm Hg diastolic in the prior 6 months. 19. Grade 2 or higher QT prolongation as measured by corrected QT interval (QTc) as calculated by the Fridericia formula at screening. 20. History of acute or chronic pancreatitis. 21. Bleeding disorder including factor deficiency, coagulopathy or platelet disorder that requires special precautions (easy bruising without a formal diagnosis is not exclusionary) or chronic anticoagulation 22. History of pulmonary embolism or deep venous thrombosis. 23. History of hereditary angioedema, acquired angioedema or idiopathic angioedema. 24. Known allergy/sensitivity or hypersensitivity to components of study drugs. 25. Unstable asthma (e.g. sudden acute attacks occurring without an obvious trigger) or asthma requiring: 1. Daily steroid or long-acting beta-agonist prevention 2. Hospitalization in the last two years 26. Active chronic skin problems such as eczema or psoriasis not controlled with topical treatments. 27. Inability to communicate effectively with study personnel.
Contact & Investigator
Cynthia L. Gay, MD
PRINCIPAL INVESTIGATOR
University of North Carolina, Chapel Hill
Frequently Asked Questions
Who can join the NCT07217379 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying HIV (Human Immunodeficiency Virus). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT07217379 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT07217379 currently recruiting?
Yes, NCT07217379 is actively recruiting participants. Contact the research team at susan_pedersen@med.unc.edu for enrollment information.
Where is the NCT07217379 trial being conducted?
This trial is being conducted at Chapel Hill, United States, Eldoret, Kenya, Kericho, Kenya.
Who is sponsoring the NCT07217379 clinical trial?
NCT07217379 is sponsored by University of North Carolina, Chapel Hill. The principal investigator is Cynthia L. Gay, MD at University of North Carolina, Chapel Hill. The trial plans to enroll 24 participants.
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