NCT06706206 The CACHE Study: Coronary Artery Care in HaEmophilia
| NCT ID | NCT06706206 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Oxford University Hospitals NHS Trust |
| Condition | Haemophilia |
| Study Type | OBSERVATIONAL |
| Enrollment | 80 participants |
| Start Date | 2025-02-25 |
| Primary Completion | 2026-07 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 80 participants in total. It began in 2025-02-25 with a primary completion date of 2026-07.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators will use state-of-the-art imaging to look at heart disease in people with haemophilia. Haemophilia is an inherited disorder in which blood does not clot properly because of lack of a key 'glue' blood component (chemicals known as factor VIII or IX). People with haemophilia are 40% less likely to die of heart disease, but it is not known exactly why this is. Understanding heart disease in people with haemophilia is important because better treatments for haemophilia mean that these patients are now living longer, but doctors still don't know if the risk for heart disease in these patients as they age is the same as that for the general population. If these processes are better understand (perhaps less blood clotting is actually protecting the heart from blockage-causing clots), scientists might be able to reduce the risk of heart attacks for everybody. The UK's first photon-counting detector cardiac CT scanner generates detailed images of the heart and its blood vessels by counting individual X-ray photons. Together with artificial intelligence tools, it is possible to extract a lot of information from these images. As people age, fat is deposited in the vessels which supply blood to the heart which forms plaques. Plaques cause narrowing of the vessels, reducing blood flow to the heart, and can also burst (rupture), leading to a blood clot and heart attack. The new CT scan will show the type and amount of plaques, and quantify the risk of plaque rupture, in people with haemophilia; and the investigators will compare this to people without haemophilia. Understanding the role of factor VIII/IX in heart attacks will improve management of heart disease in people with haemophilia, and may also lead to new prevention and treatment strategies that benefit heart health for everyone.
Eligibility Criteria
Inclusion Criteria: * Be willing and able to give informed consent for participation in the study. * Male, aged 45 years or above (no upper age limit). * Haemophilia A or B with Factor VIII/IX less than 40% (0.40 IU/ml). Exclusion Criteria: * Participants unable or unwilling to give informed consent. * Participants unable to understand the English language. * Participants unable or unwilling to attend for the necessary scans and investigations. * Patients with absolute contra-indications to CT imaging will be excluded from the study. This includes: * Any known contraindications to CT iodinated Contrast. * Significant renal impairment (eGFR \<30 ml/min). * Any other medical conditions which would influence the reliability of the study results determined by the investigators.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06706206 clinical trial?
This trial is open to male participants only, aged 45 Years or older, up to 120 Years, studying Haemophilia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06706206 currently recruiting?
Yes, NCT06706206 is actively recruiting participants. Contact the research team at susie.shapiro@ouh.nhs.uk for enrollment information.
Where is the NCT06706206 trial being conducted?
This trial is being conducted at Oxford, United Kingdom.
Who is sponsoring the NCT06706206 clinical trial?
NCT06706206 is sponsored by Oxford University Hospitals NHS Trust. The trial plans to enroll 80 participants.