NCT05163600 The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)
| NCT ID | NCT05163600 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Zurich |
| Condition | COPD |
| Study Type | INTERVENTIONAL |
| Enrollment | 24 participants |
| Start Date | 2022-05-20 |
| Primary Completion | 2026-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 24 participants in total. It began in 2022-05-20 with a primary completion date of 2026-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.
Eligibility Criteria
Inclusion and exclusion for the healthy participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Clinically healthy Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg Inclusion and exclusion for the COPD participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Diagnosed COPD according to GOLD-guidelines12 Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Acute or recent (within the last 6 weeks) exacerbation of COPD * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg
Contact & Investigator
Christian Clarenbach, Dr. med
PRINCIPAL INVESTIGATOR
University of Zurich
Frequently Asked Questions
Who can join the NCT05163600 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying COPD. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05163600 currently recruiting?
Yes, NCT05163600 is actively recruiting participants. Contact the research team at Christian.clarenbach@usz.ch for enrollment information.
Where is the NCT05163600 trial being conducted?
This trial is being conducted at Zurich, Switzerland.
Who is sponsoring the NCT05163600 clinical trial?
NCT05163600 is sponsored by University of Zurich. The principal investigator is Christian Clarenbach, Dr. med at University of Zurich. The trial plans to enroll 24 participants.
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