NCT05163600 The Acute Cardiorespiratory Response to Blood-flow Restricted Versus Traditional Exercise Training Regimens (CaRe BFR)

Trial Parameters

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Brief Summary

The investigators hypothesize that BFR exercise regimens result in a different acute cardiorespiratory response pattern compared to traditional exercise regimens. Furthermore, the investigators hypothesize that these patterns differ between healthy participants and participants with COPD. Regarding secondary objective, the investigators hypothesize that BFR results in lower blood pressure responses compared to traditional exercise training in both healthy and COPD participants.

Eligibility Criteria

Inclusion and exclusion for the healthy participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Clinically healthy Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure \<100 mmHg Inclusion and exclusion for the COPD participants are defined by the following criteria. Inclusion criteria: * Age ≥ 18 years * Diagnosed COPD according to GOLD-guidelines12 Exclusion criteria: * Physical or intellectual impairment precluding informed consent or protocol adherence * Non-German speaking (precluding informed consent) * Acute or recent (within the last 6 weeks) exacerbation of COPD * Pain during exercise of any origin * Pregnancy * History of thromboembolic event in the lower extremity * Resting systolic blood pressure

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