NCT07340255 The 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction
| NCT ID | NCT07340255 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Affiliated Hospital of Jiaxing University |
| Condition | Airway Management |
| Study Type | INTERVENTIONAL |
| Enrollment | 60 participants |
| Start Date | 2025-09-29 |
| Primary Completion | 2026-02 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 60 participants in total. It began in 2025-09-29 with a primary completion date of 2026-02.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Exploring the 90% Effective Ventilation Pressure (EP90) for Esophageal Insufflation Avoidance During Anesthesia Induction: The aim is to determine the optimal ventilation pressure for esophageal insufflation avoidance during anesthesia induction and to explore its guiding significance for anesthesia management. The goal is to provide a more precise and personalized ventilation pressure setting standard for clinical anesthesia, thereby enhancing the safety of the anesthesia induction phase.
Eligibility Criteria
Inclusion Criteria: 1. Age: 18-65 years, regardless of gender; 2. ASA classification: I-III; 3. Scheduled for elective general anesthesia surgery; 4. BMI: 18.0-28.0 kg/m²; 5. Preoperative fasting: Solid food \>6 hours, liquid \>2 hours; 6. Less than two from five criteria predicting difficult mask ventilation as described by Langeron et al.(Prediction of difficult mask ventilation. Anesthesiology 2000; 92:1229-36); 7. No severe underlying conditions such as heart, lung, liver, or kidney disease; 8. Signed informed consent and ability to cooperate with the study protocol. Exclusion Criteria: 1. Pregnant or breastfeeding women; 2. History of upper gastrointestinal diseases such as gastroesophageal reflux disease, peptic ulcers, or hiatal hernia; 3. Recent (within 2 weeks) respiratory infections, chronic cough, similar symptoms, and other known or predictable respiratory system diseases; 4. Need for emergency surgery or airway obstruction after anesthesia induction requiring urgent intubation; 5. Inability to achieve adequate oxygenation during mask ventilation (e.g., SpO₂ \< 92% for 30 seconds, unresponsive to treatment); 6. History of contraindications or allergies to study medications; 7. Inability to understand the study content or refusal to cooperate; 8. Oropharyngeal or facial pathology; 9. with an indwelling gastric tube, and who had previously undergone gastric surgery.
Contact & Investigator
Qinghe Zhou, Dr.
STUDY CHAIR
Affiliated Hospital of Jiaxing University
Frequently Asked Questions
Who can join the NCT07340255 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Airway Management. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07340255 currently recruiting?
Yes, NCT07340255 is actively recruiting participants. Contact the research team at zqh10980@zjxu.edu.edu.cn for enrollment information.
Where is the NCT07340255 trial being conducted?
This trial is being conducted at Jiaxing, China.
Who is sponsoring the NCT07340255 clinical trial?
NCT07340255 is sponsored by Affiliated Hospital of Jiaxing University. The principal investigator is Qinghe Zhou, Dr. at Affiliated Hospital of Jiaxing University. The trial plans to enroll 60 participants.