Trial Parameters
Condition Inflammatory Bowel Diseases
Sponsor Children's Hospital of Fudan University
Study Type OBSERVATIONAL
Phase N/A
Enrollment 40
Sex ALL
Min Age 28 Days
Max Age 6 Years
Start Date 2024-05-15
Completion 2025-12-31
Interventions
Thalidomide
Brief Summary
This is a single center, observational study to investigate the clinical outcomes of thalidomide treatment for very early onset inflammatory bowel disease
Eligibility Criteria
Inclusion Criteria: * diagnosed with inflammatory bowel disease * disease onset less than 6 years old * Pediatric Crohn's disease Activity Index (PCDAI)\>30 or Pediatric Ulcerative Colitis Activity Index (PUCAI)\>35 * patients and their legal guardians were willing to receive thalidomide treatment and participate in this study. Exclusion Criteria: * liver dysfunction * allergy to thalidomide * with Neuropathy * with thrombosis * thalidomide treatment in the previous 30 days * biologics treatment in the previous 8 weeks * not suitable participated in this study