NCT06986278 tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
| NCT ID | NCT06986278 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Castilla-La Mancha |
| Condition | tDCS |
| Study Type | INTERVENTIONAL |
| Enrollment | 78 participants |
| Start Date | 2025-05-26 |
| Primary Completion | 2025-08-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 78 participants in total. It began in 2025-05-26 with a primary completion date of 2025-08-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
Eligibility Criteria
Inclusion Criteria: * Ability to understand and follow instructions. * Diagnosis of Multiple Sclerosis according to McDonald criteria. * Expanded Disability Status Scale (EDSS) between 1 and 6. * Stable condition in the last three months. Exclusion Criteria: * Peripheral neurological injury of lower limbs. * Metal objects in the head. * Uncontrolled epilepsy. * Diagnosis of psychiatric disorder. * Fractures or fissures in the skull. * Presence of any implanted electronic device (pacemaker, baclofen pump). * Presence of ulcers in the harness attachment area. * Osteoporotic fractures in the last 2 years. * Height \> 190 cm. * Weight \> 120 kg.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06986278 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying tDCS. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06986278 currently recruiting?
Yes, NCT06986278 is actively recruiting participants. Contact the research team at diego.serrano@uclm.es for enrollment information.
Where is the NCT06986278 trial being conducted?
This trial is being conducted at Toledo, Spain, Toledo, Spain.
Who is sponsoring the NCT06986278 clinical trial?
NCT06986278 is sponsored by University of Castilla-La Mancha. The trial plans to enroll 78 participants.