NCT06564623 Targeting Driver Oncogenes With a Peptide Vaccine Plus Durvalumab and Tremelimumab for Patients With Biliary Tract Cancers (BTC)
| NCT ID | NCT06564623 |
| Status | Recruiting |
| Phase | Phase 1 |
| Sponsor | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
| Condition | Biliary Tract Cancers |
| Study Type | INTERVENTIONAL |
| Enrollment | 25 participants |
| Start Date | 2025-05-27 |
| Primary Completion | 2029-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 1 is the earliest stage of human testing — safety and dosage are the primary focus. Visits are frequent and medical supervision is intensive. You will be among the first people to receive this treatment.
This trial targets 25 participants in total. It began in 2025-05-27 with a primary completion date of 2029-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to evaluate the safety and the immune response of personalized mutant peptide vaccine with poly-ICLC adjuvant (mBTCvax) in combination with durvalumab and tremelimumab following front-line treatment in patients with advanced stage BTC.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years * Must have a histologically- or cytologically, proven biliary tract cancer (BTC) previously treated with gemcitabine/cisplatin/anti-PD(L)1 therapy. * Must have evidence of radiological disease, must accept to have a tumor biopsy of an accessible lesion at baseline and on treatment. * Must have sufficient archival tumor tissue for next-generation sequencing (NGS) and immune-phenotyping. * Have a BTC containing at least one of the oncogenic mutation/alterations targeted by the vaccine. * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1. * Must have body weight of \>30 kg. * Patients must have adequate organ and marrow function defined by study-specified laboratory tests. * Patients with chronic or acute hepatitis B virus (HBV) or hepatitis C virus (HCV) infection must have disease controlled prior to enrollment. * Women of childbearing potential (WOCBP) must have a negative urine or serum pregnancy test. * For both Women and Men, must use acceptable form of birth control while on study. * Must have a life expectancy of at least 12 weeks. * Ability to understand and willingness to sign a written informed consent document. Exclusion Criteria: * Participation in another clinical study with an investigational product during the last 2 weeks. * Patient is expected to require any other form of systemic or localized antineoplastic therapy while on study. * Any of the following procedures or medications within 2 weeks prior to initiation of study treatment: * Systemic or topical steroids at immunosuppressive doses (\> 10 mg/day of prednisone or equivalent). The following are exceptions to this criterion: * Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection) * Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent * Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication) * Palliative or adjuvant radiation or gamma knife radiosurgery. * Chemotherapy or checkpoint inhibitor targeting anti-Pd1/PD-L1. * Within 4 weeks prior to initiation of study treatment: * Any investigational cytotoxic drug. * Any investigational device. * Non-oncology vaccines containing live virus. * Allergen hyposensitization therapy. * Growth factors, e.g. granulocyte-colony stimulating factor (G-CSF), granulocyte macrophage-colony stimulating factor (GM-CSF), erythropoietin. * Major surgery. * Any unresolved toxicity NCI CTCAE Grade ≥2 from previous anticancer therapy with the exception of alopecia, vitiligo, and the laboratory values defined in the inclusion criteria. * Patients with Grade ≥2 neuropathy will be evaluated on a case-by-case basis after consultation with the Study Physician. * All AEs while receiving prior immunotherapy must have completely resolved or resolved to baseline prior to screening for this study. * Must not have experienced a ≥Grade 3 immune related AE or an immune related neurologic or ocular AE of any grade while receiving prior immunotherapy. * Patients with a history of prior treatment with anti-PD-1 and anti-PD-L1. * History of severe hypersensitivity reaction to any monoclonal antibodies or related compounds or to any of its components. * History of leptomeningeal carcinomatosis. * Patient has a known history or evidence of brain metastases. * Has an active known or suspected autoimmune disease or which has required systemic therapy in the last 5 years. * Known history of interstitial lung disease or of (non-infectious) pneumonitis that required steroids or current pneumonitis. * Has a pulse oximetry \< 92% on room air. * Requires the use of home oxygen. * Has a known history of Human Immunodeficiency Virus (HIV)/AIDS * Has active co-infection with HBV (hepatitis B virus) and HCV (hepatitis C virus) or coinfected with HBV and hepatitis delta virus (HDV) * Uncontrolled intercurrent illness including, but not limited to, uncontrolled infection, symptomatic congestive heart failure, unstable angina, cardiac arrhythmia, metastatic cancer, or psychiatric illness/social situations that would limit compliance with study requirements. * Patients who have been diagnosed with another cancer or myeloproliferative disorder in the past 5 years requiring systemic therapy or expected to require active therapy within the clinical study period. * Has a diagnosis of immunodeficiency. * Presence of any tissue or organ allograft, regardless of need for immunosuppression, including corneal allograft. Patients with a history of allogeneic hematopoietic stem cell transplant will be excluded. * Any other sound medical, psychiatric, and/or social reason as determined by the Investigator. * Patient is at the time of signing informed consent a regular user (including "recreational use") of any illicit drugs or had a recent history (within the last year) of substance abuse (including alcohol). * Patient is unwilling or unable to follow the study schedule for any reason. * Pregnant or breastfeeding. * WOCBP and men with female partners (WOCBP) who are not willing to use contraception. * Evidence of clinical ascites requiring paracentesis in the last 4 weeks. * History of malignant bowel obstruction.
Contact & Investigator
Marina Baretti, MD
PRINCIPAL INVESTIGATOR
SKCCC Johns Hopkins Medical Institution
Frequently Asked Questions
Who can join the NCT06564623 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Biliary Tract Cancers. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT06564623 trial and what does that mean for participants?
Phase 1 trials are the first stage of human testing. The primary goal is to assess safety and determine appropriate dosage levels. Participants are closely monitored. These trials typically involve a small number of volunteers.
Is NCT06564623 currently recruiting?
Yes, NCT06564623 is actively recruiting participants. Contact the research team at GIClinicalTrials@jhmi.edu for enrollment information.
Where is the NCT06564623 trial being conducted?
This trial is being conducted at Baltimore, United States.
Who is sponsoring the NCT06564623 clinical trial?
NCT06564623 is sponsored by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. The principal investigator is Marina Baretti, MD at SKCCC Johns Hopkins Medical Institution. The trial plans to enroll 25 participants.
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