NCT01627301 Sympathetic Overactivity in Post-traumatic Stress Disorder
| NCT ID | NCT01627301 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Emory University |
| Condition | Post-traumatic Stress Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2012-07 |
| Primary Completion | 2027-12 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2012-07 with a primary completion date of 2027-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension. One potential mechanism is overactivation of the sympathetic nervous system (SNS), both at rest and particularly during stress. This study will evaluate whether 8 weeks of daily DGB therapy or transcutaneous vagus nerve stimulation (tVNS) therapy improves SNS activity at rest and during stress.
Eligibility Criteria
Inclusion Criteria: * prehypertensive and normotensive veterans with PTSD, and prehypertensive and normotensive veterans without PTSD (controls) Exclusion Criteria: * heart or vascular disease * illicit drug use within the last 6 months * excessive alcohol use (\>2 drinks per day) * pregnancy * autonomic dysfunction * medications known to affect SNS (clonidine) * treatment with monoamine oxidase (MAO) inhibitors within the last 14 days * any serious systemic disease
Contact & Investigator
Jeanie Park, MD
PRINCIPAL INVESTIGATOR
Emory University and the Atlanta VA Medical Center
Frequently Asked Questions
Who can join the NCT01627301 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Post-traumatic Stress Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT01627301 currently recruiting?
Yes, NCT01627301 is actively recruiting participants. Contact the research team at deirdre.dixon@emory.edu for enrollment information.
Where is the NCT01627301 trial being conducted?
This trial is being conducted at Decatur, United States.
Who is sponsoring the NCT01627301 clinical trial?
NCT01627301 is sponsored by Emory University. The principal investigator is Jeanie Park, MD at Emory University and the Atlanta VA Medical Center. The trial plans to enroll 120 participants.