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Recruiting NCT06373679

NCT06373679 Switch or Quit R01

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Clinical Trial Summary
NCT ID NCT06373679
Status Recruiting
Phase
Sponsor Medical University of South Carolina
Condition Cigarette Smoking
Study Type INTERVENTIONAL
Enrollment 225 participants
Start Date 2024-07-10
Primary Completion 2027-05-01

Eligibility & Interventions

Sex All sexes
Min Age 21 Years
Max Age N/A
Study Type INTERVENTIONAL
Interventions
Switching to E-CigaretteSwitching using Medication

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.

This trial targets 225 participants in total. It began in 2024-07-10 with a primary completion date of 2027-05-01.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

This study evaluates whether non-cigarette tobacco products (e-cigarettes) can help smokers quit smoking as compared to traditional quit methods (nicotine replacement therapy or varenicline/Chantix). Participants in this study will be randomly assigned to one of two groups, then will have a choice between the offered products of that group. Participants in the e-cigarette group will have a choice of e-cigarette brand and flavor. Participants in the medication group will have choice between nicotine replacement therapy (patches and lozenges) or varenicline, also known as Chantix. Participation will last 6 months and will include weekly phone calls for the initial 7-weeks plus a 11-week phone call and a 6-month follow-up visit. Participants will also complete electronic daily diaries during the first 7-weeks.

Eligibility Criteria

Inclusion Criteria * Adults 21+ who previously had a quit attempt using FDA-approved pharmacotherapy. * Interest in reducing harms from tobacco use or quitting smoking Exclusion Criteria * Pregnant, breastfeeding, or trying to become pregnant. * Household member currently enrolled in the study * Planning to move out of the area within the next 7 months

Contact & Investigator

Central Contact

Tracy Smith, PhD

✉ smithtra@musc.edu

📞 (843)-792-5164

Principal Investigator

Tracy Smith

PRINCIPAL INVESTIGATOR

smithtra@musc.edu

Frequently Asked Questions

Who can join the NCT06373679 clinical trial?

This trial is open to participants of all sexes, aged 21 Years or older, studying Cigarette Smoking. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT06373679 currently recruiting?

Yes, NCT06373679 is actively recruiting participants. Contact the research team at smithtra@musc.edu for enrollment information.

Where is the NCT06373679 trial being conducted?

This trial is being conducted at Charleston, United States.

Who is sponsoring the NCT06373679 clinical trial?

NCT06373679 is sponsored by Medical University of South Carolina. The principal investigator is Tracy Smith at smithtra@musc.edu. The trial plans to enroll 225 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology