NCT07431125 Surgical-Clinical Correlation in Unilateral Conductive Hearing Loss With Intact Tympanic Membrane
| NCT ID | NCT07431125 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Al-Azhar University |
| Condition | Conductive Hearing Loss, Unilateral |
| Study Type | INTERVENTIONAL |
| Enrollment | 100 participants |
| Start Date | 2026-01-01 |
| Primary Completion | 2026-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 100 participants in total. It began in 2026-01-01 with a primary completion date of 2026-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Unilateral conductive hearing loss (UCHL) in the presence of an intact tympanic membrane represents a diagnostic challenge in otologic practice. In the absence of middle ear effusion or tympanic membrane pathology, stapes fixation secondary to otosclerosis is often considered the most probable diagnosis. However, although otosclerosis is traditionally regarded as a bilateral disease, clinical presentation may be unilateral due to asymmetric disease progression or subclinical contralateral involvement. Other etiologies, including congenital ossicular anomalies, ossicular discontinuity, tympanosclerosis without tympanic membrane involvement, or oval window abnormalities, may mimic otosclerosis both clinically and audiologically. Consequently, exploratory tympanotomy remains the gold standard for definitive diagnosis, allowing direct assessment of ossicular chain mobility and confirmation of stapes fixation. Correlating preoperative clinical suspicion with intraoperative findings is therefore essential to better define the true causes of unilateral conductive hearing loss with an intact tympanic membrane.
Eligibility Criteria
Inclusion Criteria: * unilateral conductive hearing loss or mixed HL with intact Tympanic Membrane * Average Airborne Gap Above 20 decibels Exclusion Criteria * Sensorineural hearing loss * Chronic otitis media * TM perforation * Previous ear surgery
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07431125 clinical trial?
This trial is open to participants of all sexes, studying Conductive Hearing Loss, Unilateral. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07431125 currently recruiting?
Yes, NCT07431125 is actively recruiting participants. Contact the research team at ethicscommitt0ee@azhar.edu.eg for enrollment information.
Where is the NCT07431125 trial being conducted?
This trial is being conducted at Asyut, Egypt.
Who is sponsoring the NCT07431125 clinical trial?
NCT07431125 is sponsored by Al-Azhar University. The trial plans to enroll 100 participants.