NCT06142773 Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN)
| NCT ID | NCT06142773 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Health Network, Toronto |
| Condition | Ventilation Therapy; Complications |
| Study Type | INTERVENTIONAL |
| Enrollment | 10 participants |
| Start Date | 2023-11-30 |
| Primary Completion | 2026-11-30 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 10 participants in total. It began in 2023-11-30 with a primary completion date of 2026-11-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells. There is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brain activity is the first step to investigating therapies to prevent brain cell injury due to the use of breathing machines to assist breathing.
Eligibility Criteria
Inclusion Criteria: 1. Patients scheduled to undergo an MRI scan of their head under general anesthesia 2. Age \> 18 years Exclusion Criteria: 1. Stroke, and/or brain tumor in the regions of interest that has not been diagnosed before the MRI scan 2. Previous medical history of dementia 3. Previous medical history of brain surgery 4. Acute or chronic spinal cord Injury 5. Previous Vagotomy 6. Phrenic nerve injury
Contact & Investigator
Ewan Goligher, MD
PRINCIPAL INVESTIGATOR
University Health Networ
Frequently Asked Questions
Who can join the NCT06142773 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Ventilation Therapy; Complications. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06142773 currently recruiting?
Yes, NCT06142773 is actively recruiting participants. Contact the research team at rongyu.jin@uhn.ca for enrollment information.
Where is the NCT06142773 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT06142773 clinical trial?
NCT06142773 is sponsored by University Health Network, Toronto. The principal investigator is Ewan Goligher, MD at University Health Networ. The trial plans to enroll 10 participants.