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Recruiting NCT04219956

Study to Evaluate the Efficacy of a Polyamine-deficient Diet for Treating Postoperative Pain After Abdominal Surgery

Trial Parameters

Condition Digestive System Surgical Procedures
Sponsor Nantes University Hospital
Study Type INTERVENTIONAL
Phase N/A
Enrollment 278
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2020-02-03
Completion 2027-04
Interventions
Polyamine Deficient Diet

Brief Summary

The aim of this study is to evaluate if a polyamine deficient diet started 7 days prior to a major abdominal surgery (eventration cure and digestive continuity) and followed 7 days post-surgery reduces the area under the curve of the numerical pain rating scale in the 72 hours post-surgery.

Eligibility Criteria

Inclusion Criteria: * Adult (\>18 years) * Indication for a " major " abdominal surgery as second surgical procedure : cure of eventration and restoration of digestive continuity * Intended Use of a Patient Controlled Morphine Pump (PCA) postoperatively or taking oral opioids * Possible follow-up during 7 months (post-operative consultation at 1 month and 6 months only if postoperative pain or complications) * Written informed consent form obtained from the patient * Affiliated to the social security Exclusion Criteria: * Pregnant women * Minor, adult under guardianship or benefiting from a legal protection * Oncological surgery * Surgery not painful (cholecystectomy, hernia, thyroidectomy, bariatric surgery) * Drug addicts patients, or under opiate dependency * Chronic pain patients (pain over 3 months) * Patients in nursing home or convalescence home (diet non possible in institution) * Planned hospitalisation before the intervention (during the 7 days before the surgery) * Severe un

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