NCT07775833 Study Protocol: The Efficacy of Mushroom to Reduce Cognitive Decline in At-Risk Middle-aged Adults and Young-olds Living in the Community
| NCT ID | NCT07775833 |
| Status | Recruiting |
| Phase | — |
| Sponsor | National University of Singapore |
| Condition | Dementia |
| Study Type | INTERVENTIONAL |
| Enrollment | 600 participants |
| Start Date | 2026-10 |
| Primary Completion | 2028-12 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 600 participants in total. It began in 2026-10 with a primary completion date of 2028-12.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The investigator's objective is to explore the definitive evidence of mushroom on cognitive functions among at-risk middle-aged and young-olds. The investigator carefully designed a randomized controlled trial (RCT) to assess the role of mushrooms in promoting cognitive functioning among around 600 middle-aged adults and young-olds. Participants were selected based on specific inclusion criteria, such as being community-living adults aged 45-80 years with a family history of dementia or subjective cognitive decline, while consuming mushrooms no more than once a week and having no dementia, along with the exclusion of individuals with neurological or psychiatric disorders and significant sensory or motor impairments. Participants in the intervention group will consume Pleurotus citrinopileatus mushroom powder daily for 24months, with compliance
Eligibility Criteria
Inclusion Criteria: * (1) Community-living adult aged 45 years to 80 years, AND * (2) Family history of Alzheimer's disease or having subjective cognitive (SCD) defined as "self-reported memory problems that have been getting worse over the past year.", AND * (3) Consume mushrooms no more than once a week, AND * (4) No dementia: CDR global score equal to zero. Exclusion Criteria: * (1) Any diagnosis of neurological diseases (e.g., epilepsy, stroke) made by a clinician, OR * (2) Any diagnosis of psychiatric illnesses (e.g., depressive disorders) made by a clinician, OR * (3) Significant sensory or motor impairments, OR * (4) Known allergy to mushrooms or a history of serious food allergies, OR * (5) Participants with a history of gout, OR * (6) Diagnosed with hyperuricemia.
Contact & Investigator
Lei FEng
PRINCIPAL INVESTIGATOR
National University of Singapore
Frequently Asked Questions
Who can join the NCT07775833 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, up to 80 Years, studying Dementia. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07775833 currently recruiting?
Yes, NCT07775833 is actively recruiting participants. Contact the research team at e1397079@u.nus.edu for enrollment information.
Where is the NCT07775833 trial being conducted?
This trial is being conducted at Singapore, Singapore.
Who is sponsoring the NCT07775833 clinical trial?
NCT07775833 is sponsored by National University of Singapore. The principal investigator is Lei FEng at National University of Singapore. The trial plans to enroll 600 participants.