NCT06144476 Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
| NCT ID | NCT06144476 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Guy's and St Thomas' NHS Foundation Trust |
| Condition | COPD |
| Study Type | OBSERVATIONAL |
| Enrollment | 230 participants |
| Start Date | 2024-02-08 |
| Primary Completion | 2026-08-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 230 participants in total. It began in 2024-02-08 with a primary completion date of 2026-08-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD). The immunopathology of these diseases is not fully understood. Matched samples from the respiratory tract and circulation will be used to identify immune patterns throughout the respiratory system to elucidate the immunopathology of airway disease.
Eligibility Criteria
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Aged 18 years or above * Patient: known or suspected airway disease * Healthy volunteer: considered to be in good health with no significant comorbidity (immune disorder, cancer etc.) Exclusion Criteria: * Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus. * Surgery within the preceding 6 weeks * Participants who are pregnant * History of psychiatric, medical, or surgical disorders that in the opinion of the chief investigator may interfere with sample collection, undergo a bronchoscopy, or may compromise study completion or data collection * Alcohol or recreational drug abuse * Diagnosis of immunodeficiency requiring treatment * Unable to provide written informed consent * Unable to read or write English * Be considered, in the opinion of the investigator, to be an unsuitable candidate for the study
Contact & Investigator
Mona Bafadhel, Prof
PRINCIPAL INVESTIGATOR
GSTT and KCL
Frequently Asked Questions
Who can join the NCT06144476 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying COPD. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06144476 currently recruiting?
Yes, NCT06144476 is actively recruiting participants. Contact the research team at gillian.radcliffe@gstt.nhs.uk for enrollment information.
Where is the NCT06144476 trial being conducted?
This trial is being conducted at London, United Kingdom.
Who is sponsoring the NCT06144476 clinical trial?
NCT06144476 is sponsored by Guy's and St Thomas' NHS Foundation Trust. The principal investigator is Mona Bafadhel, Prof at GSTT and KCL. The trial plans to enroll 230 participants.
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