NCT07084740 Study and Modeling of Perforator Flap Vascularization
| NCT ID | NCT07084740 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University Hospital, Montpellier |
| Condition | Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2026-02-15 |
| Primary Completion | 2026-07-15 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2026-02-15 with a primary completion date of 2026-07-15.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The aim of reconstructive surgery is to restore physical integrity altered by trauma, congenital malformations or cancerous pathologies. Several techniques are available, including flap surgery, which enables tissue to be moved from one anatomical location to another. Perforating skin/subcutaneous flaps are segments of skin and subcutaneous cellular tissue vascularized by a feeder vascular pedicle. This surgical technique has virtually zero donor-site morbidity, as it is no longer necessary to harvest muscle to ensure reliable vascularization of the flap. Flap vascularization is a variable mechanism, complex to describe and understand. For cutaneous and subcutaneous (fatty) flaps, which account for the majority of flaps used, perforator flaps (vascularized by a subcutaneous perforator artery) have become the benchmark. Unfortunately, their vascularization is currently poorly understood, and depends on experimental work carried out on fresh cadaveric anatomical specimens. These cadaveric studies fail to take into account several key factors influencing perforasomes (perforasome: skin territory vascularized by a pedicle), namely body temperature, blood pressure, heart rate, intraoperative patient position and biological parameters.
Eligibility Criteria
Inclusion Criteria: * Age between 18 and 70 * Reconstructive surgery using pedicled perforating flap or free perforating flap. * Flap with a surface area of at least 50 cm2 (in order to have a sufficiently large surface area for good perfusion visualization) * Pedicled perforating flaps group: Patients with pelvic eschar * Free perforating flaps group: Traumatic pathology of the lower and/or upper limb Exclusion Criteria: * No consent obtained * No social security affiliation * Persons under court protection * Persons participating in another study with an exclusion period still in progress
Contact & Investigator
Christian HERLIN, MD, PhD
PRINCIPAL INVESTIGATOR
University Hospital, Montpellier
Frequently Asked Questions
Who can join the NCT07084740 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 70 Years, studying Reconstructive Surgery Using Pedicled Perforating or Free Perforating Flaps. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07084740 currently recruiting?
Yes, NCT07084740 is actively recruiting participants. Contact the research team at c-herlin@chu-montpellier.fr for enrollment information.
Where is the NCT07084740 trial being conducted?
This trial is being conducted at Montpellier, France.
Who is sponsoring the NCT07084740 clinical trial?
NCT07084740 is sponsored by University Hospital, Montpellier. The principal investigator is Christian HERLIN, MD, PhD at University Hospital, Montpellier. The trial plans to enroll 20 participants.