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Recruiting Phase 2, Phase 3 NCT06336642

Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology

Trial Parameters

Condition Dyspnea
Sponsor M.D. Anderson Cancer Center
Study Type INTERVENTIONAL
Phase Phase 2, Phase 3
Enrollment 150
Sex ALL
Min Age 18 Years
Max Age N/A
Start Date 2024-06-11
Completion 2030-03-31
Interventions
SPOT-ON Early StartSPOT-ON Delayed Start

Brief Summary

To learn about the effect of Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology (SPOT-ON) treatment on the severity of shortness of breath in patients with cancer.

Eligibility Criteria

Inclusion Criteria: * Diagnosis of cancer * Age 18 or older. * Admitted to a medical floor. * Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst). * Speak English or Spanish. Exclusion Criteria: * Hemodynamic instability requiring active Merit Team or ICU team involvement. * Delirium as per clinical team's assessment in the Electronic Health Record (EHR). * Severe hypoxemia (SpO2 \< 90% despite supplemental oxygen of up to 6 L/min). * Continuous positive airway pressure (CPAP) use for obstructive sleep apnea, actively using \>10 hours a day. * Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment. * Patients with known pregnancy.

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