Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect
Trial Parameters
Brief Summary
The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).
Eligibility Criteria
Inclusion Criteria: * Diagnosed with ALS in the last 6 months according to Gold Coast Criteria Exclusion Criteria: * \- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview. * Lack of ability to cooperate. * Pregnancy * Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics. * Alcohol addiction defined as over 21 units weekly. * Lesional neurological diseases, such as stroke, tumor or multiple sclerosis * Epilepsy * Neurodegenerative diseases other than ALS * Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia * Contraindication for MRI and MEG scan according to hospital guidelines * Severe liver or kidney disease * Dysregulated heart disease * Ongoing treatment with any antidepressants or any antipsychotics at recruitment. * Diagnosed with frontotemporal dementia.