Medical Condition

amyotrophic lateral sclerosis

Total Trials

14

Recruiting Now

14

Trial Phases

Phase 1, Phase 2, EARLY_Phase 1

ClinicalMetric tracks all active clinical trials for amyotrophic lateral sclerosis sourced from ClinicalTrials.gov. Research in this area spans early-phase safety investigations through large Phase 3 confirmatory trials, conducted by NIH-funded academic centers, independent investigators, and pharmaceutical sponsors worldwide. Each listing is updated daily as new studies open enrollment and existing ones reach capacity or complete follow-up.

Trial listings include the NCT identifier, current recruitment status, phase classification, primary and secondary endpoints, estimated enrollment size, participating countries, and direct links to the full protocol on ClinicalTrials.gov. Eligibility criteria — including age range, disease stage, and prior treatment requirements — are documented for every study to help patients and clinicians assess suitability before contacting a trial site.

Frequently Asked Questions — amyotrophic lateral sclerosis Clinical Trials

How many clinical trials are currently recruiting for amyotrophic lateral sclerosis?

ClinicalMetric currently tracks 14 actively recruiting clinical trials for amyotrophic lateral sclerosis, sourced in real time from ClinicalTrials.gov. The total number of registered studies—including those not yet enrolling or in active follow-up—is 14. Trial availability changes daily as new studies open enrollment and existing ones reach capacity.

What trial phases are available for amyotrophic lateral sclerosis?

amyotrophic lateral sclerosis research spans Phase 1 (2 trials), Phase 2 (1 trial). Phase 1 studies evaluate safety and dosing in small groups, Phase 2 studies assess preliminary efficacy in 100–300 participants, and Phase 3 trials compare the new treatment against the standard of care in 300–3,000+ patients. Phase 4 post-approval studies monitor long-term outcomes in real-world populations.

How do I find out if I qualify for a amyotrophic lateral sclerosis clinical trial?

Eligibility criteria for amyotrophic lateral sclerosis trials vary by study and typically specify age range, disease stage or severity, prior treatment history, and specific diagnostic or laboratory parameters. Each listing on ClinicalMetric links to the full protocol on ClinicalTrials.gov, where inclusion and exclusion criteria are documented. Contact the sponsoring site's research coordinator directly to confirm your eligibility—your treating physician or specialist can also help identify the most appropriate trial based on your medical history and current treatment status.

Trial Phases

Phase 1

Phase 2

Top Sponsors

Centers for Disease Control and Prevention 1 trial

National Institute of Neurological Disorders and Stroke (NINDS) 1 trial

Neuralink Corp 1 trial

Centre Hospitalier Universitaire de Liege 1 trial

Charlotte Vogt 1 trial

Recruiting Clinical Trials

NCT01772602

Recruiting

The National Amyotrophic Lateral Sclerosis Registry

Centers for Disease Control an...

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NCT07204977 Phase 1

Recruiting

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

National Institute of Neurolog...

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NCT06429735

Recruiting

Precise Robotically IMplanted Brain-Computer InterfacE

Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part.

Centre Hospitalier Universitai...

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NCT07341984

Recruiting

A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Enrollment

2,100 pts

Location

United States, Canad...

The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

Enrollment

1,000 pts

Location

United States, Colom...

Sponsor

Target ALS Foundation, Inc.

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NCT06344260 Phase 2

Recruiting

Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS)

Casa Sollievo della Sofferenza...

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NCT06881979

Recruiting

High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project

Istituti Clinici Scientifici M...

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NCT06820008

Recruiting

Measurement and Impact of Physical Impairment in Amyotrophic Lateral Sclerosis: Use of Digital Technologies - A Precision ALS Project

University of Dublin, Trinity ...

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NCT07224269 EARLY_Phase 1

Recruiting

Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

Leigh R. Hochberg, MD, PhD.

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NCT02567136

Recruiting

Imaging Biomarkers in ALS

University of Minnesota

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer · Last Reviewed: November 2026 · Data Methodology