NCT07401186 Stimulation-Based Modulation of Spinal and Cortical Sensory Pathways
| NCT ID | NCT07401186 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Peter C. Gerszten, MD |
| Condition | Stroke |
| Study Type | INTERVENTIONAL |
| Enrollment | 15 participants |
| Start Date | 2026-05-26 |
| Primary Completion | 2027-08 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 15 participants in total. It began in 2026-05-26 with a primary completion date of 2027-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this study is to assess cervical (neck) reflexes by intra-operatively stimulating the neck nerve roots to evoke motor responses through their connections to spinal motoneurons. This data is critical to reveal changes to the spinal sensory modulating circuitry in neurological disorders like stroke.
Eligibility Criteria
Inclusion Criteria: * All Subjects: Ages between 21 and 75 years. The minimum age is selected to age match control subjects with stroke subjects. In addition, participants outside this age range may be at an increased medical risk. * Control subjects: Patients undergoing elective posterior cervical spinal surgery that includes a decompressive laminectomy, and who will have electrophysiological monitoring performed as part of the standard of care for their procedure. * Stroke subjects: Participants must have a suffered a single, ischemic or hemorrhagic stroke more than 6 months prior to the time of enrollment with hemiparesis as a result, is undergoing a cervical epidural lead implant or undergoing elective posterior cervical spinal surgery that includes a decompressive laminectomy with electrophysiological monitoring performed as part of the standard of care. Exclusion Criteria: * Patients will be excluded from the study if they have any known neurological diseases other than stroke, such as amyotrophic lateral sclerosis, spinal muscular atrophy, spinal cord injury, autoimmune neuropathy, or sensory nerve disorders, that may affect the integrity of cervical sensory afferents. * Only patients that are eligible for surgery will be enrolled. Therefore this automatically include as exclusion criteria: pregnancy and other clinical conditions eligible for surgery. * Participants must not be on anti-spasticity or anti-epileptic medications.
Contact & Investigator
Peter C Gerszten, MD
PRINCIPAL INVESTIGATOR
University of Pittsburgh, Neurological Surgery
Frequently Asked Questions
Who can join the NCT07401186 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 75 Years, studying Stroke. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07401186 currently recruiting?
Yes, NCT07401186 is actively recruiting participants. Contact the research team at gerspc@upmc.edu for enrollment information.
Where is the NCT07401186 trial being conducted?
This trial is being conducted at Pittsburgh, United States.
Who is sponsoring the NCT07401186 clinical trial?
NCT07401186 is sponsored by Peter C. Gerszten, MD. The principal investigator is Peter C Gerszten, MD at University of Pittsburgh, Neurological Surgery. The trial plans to enroll 15 participants.
Related Trials
Related Intelligence Guides
In-depth guides covering this condition's trials, eligibility, and what to expect.