NCT04775914 STEMI Treatment Optimization by Ischemic Postconditioning and IVUS Guidance
| NCT ID | NCT04775914 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Thomas Engstrom |
| Condition | ST Elevation Myocardial Infarction |
| Study Type | INTERVENTIONAL |
| Enrollment | 2,500 participants |
| Start Date | 2021-04-01 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 2,500 participants in total. It began in 2021-04-01 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of is study is to investigate whether ischemic postconditioning (iPOST) and intravascular ultrasound-guided (IVUS) percutaneous coronary intervention (PCI) improve the clinical outcome of patients with ST-segment elevation myocardial infarction treated with primary PCI.
Eligibility Criteria
Inclusion Criteria: * Age ≥18 years * Acute onset of chest pain with \<12 hours duration * STEMI as characterized by 2 mm ST elevation in 2 or more V1 through V4 leads or presumed new left bundle branch block with minimum of 1 mm concordant ST elevation or 1 mV ST-segment elevation in the limb lead (II, III and aVF, I, aVL) and V4-V6 or ST depression in 2 or more V1 through V4 leads indicating posterior AMI. Exclusion Criteria (iPOST2): Pre-PCI TIMI flow 0 or 1 Potential pregnancy Inability to provide informed consent Unwillingness to consent Unavoidable to use thrombectomy Spontaneous coronary artery dissection Time from symptoms onset to PPCI \> 12 hours Culprit in bypass graft Other reason for not including the patient Exclusion Criteria (iSTEMI): Potential pregnancy Inability to understand information in order to provide informed consent Unwillingness to consent Spontaneous coronary artery dissection Time from symptoms inset to PPCI \> 12 hours Culprit in bypass graft Other reason
Contact & Investigator
Thomas Engstrøm, MD PhD DMSci
STUDY CHAIR
Rigshospitalet, Denmark
Frequently Asked Questions
Who can join the NCT04775914 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying ST Elevation Myocardial Infarction. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04775914 currently recruiting?
Yes, NCT04775914 is actively recruiting participants. Contact the research team at Thomas.Engstroem@regionh.dk for enrollment information.
Where is the NCT04775914 trial being conducted?
This trial is being conducted at Copenhagen, Denmark.
Who is sponsoring the NCT04775914 clinical trial?
NCT04775914 is sponsored by Thomas Engstrom. The principal investigator is Thomas Engstrøm, MD PhD DMSci at Rigshospitalet, Denmark. The trial plans to enroll 2,500 participants.