NCT07616583 Standardized Study Protocol of Percutaneous Vertebroplasty Based on Pedicle Nine-Grid Zoning Method
| NCT ID | NCT07616583 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Beijing Friendship Hospital |
| Condition | Osteoporotic Vertebral Compression Fractures |
| Study Type | INTERVENTIONAL |
| Enrollment | 68 participants |
| Start Date | 2024-01-01 |
| Primary Completion | 2026-10-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 68 participants in total. It began in 2024-01-01 with a primary completion date of 2026-10-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to verify the safety and efficacy of the pedicle "Nine-grid Zoning Method" in assisting percutaneous vertebroplasty (PVP) for the treatment of lumbar osteoporotic vertebral compression fractures (OVCF) in adults. It also aims to standardize the puncture path of PVP and optimize the intraoperative operation process. The main questions it aims to answer are: * Does the "Nine-grid Zoning Method" significantly increase the rate of achieving ideal intraoperative puncture endpoints and reduce operative time compared with the traditional pedicle puncture method? * Does the novel puncture method reduce intraoperative fluoroscopy times, radiation exposure, and the incidence of postoperative bone cement leakage without increasing surgical risks? Researchers will compare the modified PVP assisted by the "Nine-grid Zoning Method" (experimental group) with conventional PVP adopting the traditional "10 o'clock/2 o'clock" pedicle puncture point (control group) to confirm the clinical superiority and safety of the new standardized puncture path. Participants will: * Receive unilateral transpedicular PVP surgery via either the nine-grid zoning puncture path or the traditional puncture path for single-segment acute lumbar OVCF * Complete preoperative baseline examinations including bone density detection, VAS pain score, ODI functional score and SF-36 quality of life score assessment * Receive standardized intraoperative data recording covering operative time, fluoroscopy frequency, radiation dose, bone cement filling and leakage conditions * Undergo postoperative follow-up at 1 day after surgery, discharge, 3 months, 6 months and 1 year after operation, with regular imaging re-examination and scale evaluation to monitor fracture recovery and postoperative complications
Eligibility Criteria
Inclusion Criteria: * Diagnosed with single-segment acute osteoporotic lumbar vertebral compression fracture (L1-L5), confirmed by typical MRI manifestations: low signal on T1-weighted imaging and high signal on T2-weighted and STIR sequences. * First-time reception of percutaneous vertebroplasty (PVP) surgery. * Complete preoperative imaging data including X-ray, CT, and MRI/bone scan. * Aged patients who voluntarily participate in the study and sign written informed consent. Exclusion Criteria: * Patients with old vertebral compression fractures or congenital pedicle dysplasia and lesions. * With a history of bone tumors or other systematic bone metabolic diseases. * CT examination shows incomplete or ruptured posterior wall of the fractured vertebral body. * Failure to obtain signed informed consent.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07616583 clinical trial?
This trial is open to participants of all sexes, aged 50 Years or older, up to 80 Years, studying Osteoporotic Vertebral Compression Fractures. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07616583 currently recruiting?
Yes, NCT07616583 is actively recruiting participants. Contact the research team at spinefei@126.com for enrollment information.
Where is the NCT07616583 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT07616583 clinical trial?
NCT07616583 is sponsored by Beijing Friendship Hospital. The trial plans to enroll 68 participants.