NCT07222046 Spinal Neurorehabilitation for Veterans With SCI
| NCT ID | NCT07222046 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Spinal Cord Injuries |
| Study Type | INTERVENTIONAL |
| Enrollment | 40 participants |
| Start Date | 2026-08-31 |
| Primary Completion | 2031-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 40 participants in total. It began in 2026-08-31 with a primary completion date of 2031-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Chronic spinal cord injury (SCI) is a debilitating disorder in Veterans and the broader U.S. population that does not have a cure. Veterans with severe SCI demonstrate permanent loss of sensory and motor function below their injury resulting in decreased quality of life and independence. Recently, electrical spinal neuromodulation has emerged as a potential approach to restore voluntary motor function and locomotion in persons with chronic SCI. However, spinal neuromodulation has yet to translate to clinical use due to small sample sizes in research studies and a lack of information on which patients would benefit. Here, the investigators propose a novel approach to evaluate the priorities and barriers faced by Veterans with SCI to use spinal neuromodulation, understand the neural connections remaining in Veterans with severe SCI, and determine potential functional improvements using non-invasive spinal neuromodulation technology. This research represents the first step towards deploying techniques that could dramatically improve function and quality of life for Veterans with SCI.
Eligibility Criteria
Inclusion Criteria: * All participants must be able to independently read and understand study information materials necessary to ensure informed consent * All participants must have a chronic spinal cord injury occurring \>1 year prior to study enrollment * Ability to follow simple commands in English Exclusion Criteria: * Contraindications to the use of external magnetic or electrical stimulation (e.g., epilepsy, intracranial metal, implanted electrosensitive device, etc.) * Significant neurological comorbidities that may affect neurophysiological recordings * Functional disability prior to spinal cord injury * Visual or auditory disorders limiting ability to participate in study procedures * Pregnancy * Primary psychiatric disorders or dissociative mental symptoms that impair informed consent * Significant chronic pain that may preclude an magnetic resonance imaging (MRI) scan or performing neurorehabilitation exercises * Frequent and significant spasticity that may preclude an MRI scan or neurorehabilitation exercises
Contact & Investigator
Jonathan S Calvert, PhD MD
PRINCIPAL INVESTIGATOR
VA Northern California Health Care System, Mather, CA
Frequently Asked Questions
Who can join the NCT07222046 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Spinal Cord Injuries. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07222046 currently recruiting?
Yes, NCT07222046 is actively recruiting participants. Contact the research team at Jonathan.Calvert2@va.gov for enrollment information.
Where is the NCT07222046 trial being conducted?
This trial is being conducted at Sacramento, United States.
Who is sponsoring the NCT07222046 clinical trial?
NCT07222046 is sponsored by VA Office of Research and Development. The principal investigator is Jonathan S Calvert, PhD MD at VA Northern California Health Care System, Mather, CA. The trial plans to enroll 40 participants.