NCT03657524 Speckle Tracking Echocardiography for the Prediction of Weaning Failure
| NCT ID | NCT03657524 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Assistance Publique Hopitaux De Marseille |
| Condition | Weaning Failure of Mechanical Ventilation |
| Study Type | INTERVENTIONAL |
| Enrollment | 110 participants |
| Start Date | 2019-05-20 |
| Primary Completion | 2026-05-21 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 110 participants in total. It began in 2019-05-20 with a primary completion date of 2026-05-21.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Deciding the optimal timing for extubation in patients who are mechanically ventilated can be challenging, and traditional weaning predictor tools are not accurate. Recent studies suggest that isolated sonographic assessment of the respiratory and cardiac function (ie diastolic function and filling pressure), in mechanically ventilated patients may assist in identifying patients at risk of weaning failure. Recently, the association of conventional echocardiography and lung ultrasound showed promising results for the prediction of post extubation distress. Speckle Tracking is an emerging tool in intensive care medicine that has never been investiguated for the prediction of weaning failure. It could early detects diastolic dysfunction and and elevated filling pressure. Of more, speckle tracking is known to be less operator dependant. The main objective of our study is to evaluate the diagnosis accuracy of speckle tracking echocardiography performed during a weaning trial to predict weaning failure. The secondary objectives are to assess the diagnosis accuracy of combined heart and lung ultrasound to predict weaning failure.
Eligibility Criteria
Inclusion Criteria: \- Patients hospitalized in intensive care unit under mechanical fulfilling the criteria of ventilation weaning trial. Exclusion Criteria: * Less than 18 years old. * Pregnancy * Non sinusal cardiac rhythm * Neuro Myopathy * Tracheotomy * Lack of echogenicity to perform at least a four chamber apical view
Frequently Asked Questions
Who can join the NCT03657524 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Weaning Failure of Mechanical Ventilation. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT03657524 currently recruiting?
Yes, NCT03657524 is actively recruiting participants. Visit ClinicalTrials.gov or contact Assistance Publique Hopitaux De Marseille to inquire about joining.
Where is the NCT03657524 trial being conducted?
This trial is being conducted at Marseille, France.
Who is sponsoring the NCT03657524 clinical trial?
NCT03657524 is sponsored by Assistance Publique Hopitaux De Marseille. The trial plans to enroll 110 participants.