NCT07580183 Spatial Scene Recognition Memory in Epilepsy Surgery
| NCT ID | NCT07580183 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of California, Davis |
| Condition | Focal Epilepsy |
| Study Type | INTERVENTIONAL |
| Enrollment | 620 participants |
| Start Date | 2024-07-01 |
| Primary Completion | 2030-06-30 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 620 participants in total. It began in 2024-07-01 with a primary completion date of 2030-06-30.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions. Standard neuropsychological tests are insensitive to important memory deficits experienced by patients, particularly in spatial/scene memory, recollective experience, and familiarity processing. Using a validated virtual tour paradigm, the study examines how familiarity-based recognition and recall of spatial scenes relate to specific brain structures. In Aim I, a large cohort of patients with varied temporal lobe lesions at Emory University undergoes the virtual tour task with voxel-based lesion-symptom mapping to localize necessary brain regions. In Aim II, scalp event-related potentials and eye tracking in healthy participants at UC Davis characterize the temporal dynamics and lateralization of scene recognition. In Aim III, intracranial EEG recordings (including local field potentials and single-unit activity) in epilepsy surgery patients at UC Davis determine the precise network dynamics underlying spatial scene familiarity and recall. The long-term goal is to improve the prediction and prevention of cognitive morbidity from epilepsy surgery by providing a more complete model of spatial recognition memory circuits.
Eligibility Criteria
Inclusion Criteria: * Age 18 years or older * For Aims I and III: Diagnosis of focal epilepsy or temporal lobe lesion; patients undergoing evaluation for or having undergone epilepsy surgery * For Aim II: Healthy adult participants * Full-Scale IQ ≥ 70 * English proficiency sufficient to understand and complete the task * For Aim I: Enrolled in or eligible for Emory University epilepsy surgery research registry * For Aim III: Undergoing clinically indicated stereoelectroencephalography (SEEG) at UC Davis Medical Center * Able to provide informed consent (or for Aim I retrospective component, prior consent in Emory registry) Exclusion Criteria: * Full-Scale IQ \< 70 * Inability to provide informed consent * For Aim III: Age \> 55 years * For Aim II: History of neurological or psychiatric disorder (as applicable per study protocol)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07580183 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 55 Years, studying Focal Epilepsy. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07580183 currently recruiting?
Yes, NCT07580183 is actively recruiting participants. Contact the research team at nppedersen@health.ucdavis.edu for enrollment information.
Where is the NCT07580183 trial being conducted?
This trial is being conducted at Sacramento, United States, Atlanta, United States.
Who is sponsoring the NCT07580183 clinical trial?
NCT07580183 is sponsored by University of California, Davis. The trial plans to enroll 620 participants.
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