NCT07712419 Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
| NCT ID | NCT07712419 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Gaziosmanpasa Research and Education Hospital |
| Condition | Knee Osteoarthritis |
| Study Type | OBSERVATIONAL |
| Enrollment | 30 participants |
| Start Date | 2026-05-15 |
| Primary Completion | 2026-09 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 30 participants in total. It began in 2026-05-15 with a primary completion date of 2026-09.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably. Identifying imaging biomarkers that predict clinical response may improve patient selection and optimize treatment outcomes. This prospective observational study aims to evaluate whether the Sonographic Thigh Adjustment Ratio (STAR), calculated as anterior quadriceps muscle thickness divided by body mass index (BMI), and subcutaneous fat thickness are associated with pain relief following genicular nerve block in patients with symptomatic knee osteoarthritis. Ultrasound measurements will be obtained before the procedure, and clinical outcomes will be assessed during follow-up. The primary objective is to determine whether sonographic muscle parameters can predict treatment response after GNB.
Eligibility Criteria
Inclusion Criteria: * Age ≥45 years. * Symptomatic bilateral knee osteoarthritis with Kellgren-Lawrence grade 3 or 4. * Visual Analog Scale (VAS) pain score ≥4 at rest or during movement. * Scheduled to undergo first ultrasound-guided genicular nerve block. * No intra-articular knee injection within the previous 3 months. * Considered unsuitable for or awaiting total knee arthroplasty. * Ability to provide written informed consent. Exclusion Criteria: * Inflammatory arthritis, rheumatoid arthritis, or crystal arthropathy. * Previous knee surgery or knee prosthesis. * Active local or systemic infection. * Anticoagulant therapy or bleeding disorders. * Contraindication to corticosteroids (including uncontrolled diabetes mellitus). * Allergy to study medications. * Neurological disorders causing neuropathic knee pain. * Dementia or inability to complete study assessments. * Additional interventional procedures or surgery during follow-up.
Frequently Asked Questions
Who can join the NCT07712419 clinical trial?
This trial is open to participants of all sexes, aged 45 Years or older, studying Knee Osteoarthritis. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07712419 currently recruiting?
Yes, NCT07712419 is actively recruiting participants. Visit ClinicalTrials.gov or contact Gaziosmanpasa Research and Education Hospital to inquire about joining.
Where is the NCT07712419 trial being conducted?
This trial is being conducted at Istanbul, Turkey (Türkiye).
Who is sponsoring the NCT07712419 clinical trial?
NCT07712419 is sponsored by Gaziosmanpasa Research and Education Hospital. The trial plans to enroll 30 participants.