Somatic Mosaicism in Twins Discordant for Childhood Cancer
Trial Parameters
Brief Summary
Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.
Eligibility Criteria
Inclusion Criteria: * Newly diagnosed patient with CNS tumor or have recurrent disease and enrolled on APEC14B1. * Patient must have same sex twin. Note: (history of) treatment on a COG therapeutic trial is not required. * Patients must be diagnosed at \< 19 years of age at the time of diagnosis. * A family is eligible to participate if the twin with the CNS tumor is deceased but has a blood sample banked through APEC14B1. * All patients and/or their parents or legal guardians must provide informed consent. Assent will be obtained for participants between the ages of 8-17 years. * All institutional, FDA, and NCI requirements for human studies must be met.