NCT06482814 Sleep Restriction and Parental History of Hypertension
| NCT ID | NCT06482814 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Mayo Clinic |
| Condition | Hypertension |
| Study Type | INTERVENTIONAL |
| Enrollment | 44 participants |
| Start Date | 2025-02-20 |
| Primary Completion | 2029-04 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 44 participants in total. It began in 2025-02-20 with a primary completion date of 2029-04.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The purpose of this study is to research the effects of partial sleep deprivation (sleep restriction) in a group of individuals whose parents have high blood pressure compared to a group of individuals whose parents have normal blood pressure.
Eligibility Criteria
Inclusion Criteria * Healthy adults aged 18-35 years * Absence of any significant medical or psychiatric disease (as per the investigators' judgment) * Nonsmoker * Nonpregnant * History of normal sleep duration (reported average sleep duration between 7-9 hours/night and no habitual napping) * Hypertension status information available for both biological parents * Ability to understand study procedures and to comply with them for the entire length of the study * Ability to understand English and provide informed consent Exclusion Criteria * Age \<18 or \>35 years * Body mass index \<18.5 or ≥30 kg/m2 * Pregnant or lactating * Unable to determine history of HTN in participant's biological parents or subject being adopted * Use of tobacco, vaping, marijuana products or other drugs * Excessive caffeine consumption (\>400 mg/day) * Excessive alcohol consumption (\>7 drinks/week for women, \>14 drinks/week for men) * Office SBP/DBP ≥130/80 mmHg * Daytime ambulatory SBP/DBP ≥130/80 mmHg * Fasting glucose ≥126 mg/dl * Glomerular filtration rate \<60 mL/min/BSA * History of significant medical or psychiatric disorders (as per the investigators' judgment) * Regular use of prescription medications other than contraceptives * Use of melatonin supplements or any other over-the-counter sleep aid * Moderate-to-severe sleep disordered breathing (apnea/hypopnea index, AHI ≥15) or mild sleep disordered breathing (AHI 5-15) with daytime sleepiness (Epworth Sleepiness Scale \>10) * Moderate-to-severe insomnia (Insomnia Severity Index \>14) * Restless leg syndrome (as per the Cambridge-Hopkins questionnaire) * Excessive daytime sleepiness (Epworth Sleepiness Scale \>15) * Extreme chronotype (Morningness-Eveningness Questionnaire \>69 or \<31) * Night shift work * Ongoing participation in other research studies (as per the investigators' judgment) * Any other medical, geographic, or social factor making study participation impractical * Not English-speaking and/or inability to provide informed consent * Exclusionary for blood draws: hemoglobin \<11.6 g/dL in women / \<13.2 g/dL in men; participants with measured hemoglobin levels below these thresholds will be allowed to continue participate in study tests and procedures not involving blood draws.
Contact & Investigator
Naima Covassin, Ph.D
PRINCIPAL INVESTIGATOR
Mayo Clinic
Frequently Asked Questions
Who can join the NCT06482814 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 35 Years, studying Hypertension. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06482814 currently recruiting?
Yes, NCT06482814 is actively recruiting participants. Contact the research team at Munir.Sabah@mayo.edu for enrollment information.
Where is the NCT06482814 trial being conducted?
This trial is being conducted at Rochester, United States.
Who is sponsoring the NCT06482814 clinical trial?
NCT06482814 is sponsored by Mayo Clinic. The principal investigator is Naima Covassin, Ph.D at Mayo Clinic. The trial plans to enroll 44 participants.