| NCT ID | NCT05775627 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Oregon Health and Science University |
| Condition | Sleep Deprivation |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2023-12-01 |
| Primary Completion | 2027-06-30 |
Trial Parameters
Eligibility Fast-Check
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Brief Summary
The goal of this study is to uncover sleep and circadian mechanisms contributing to adverse metabolic health. The protocol is a 21 day (7 outpatient days, 14 inpatient days) mechanistic randomized-crossover study designed to identify the impact of chronic sleep restriction and circadian timing, independently and in combination on energy metabolism and identify the independent and combined effects on glucose tolerance.
Eligibility Criteria
Inclusion Criteria: * Between 18 and 40 years of age * Drug free * Established disease-free status Exclusion Criteria: 1. Dietary restrictions Participants must not have dietary restrictions that could systematically bias their macronutrient intake. The following will exclude participants from enrolling in the study based on their diet: * Participants who choose not to or cannot consume dairy products (milk, yogurt, cheese, ice cream) 2. Body Composition A body mass index (BMI) of 18.5\< \[BMI\] \< 25 kg/m2 and a waist circumference \<94/80cm. 3. Psychiatric/psychological suitability Each participant will undergo a structured interview (Mini International Neuropsychiatric Interview) with a qualified OHSU physician. This physician will supervise the administration and scoring of a Beck Depression Inventory II (BDI-II) questionnaire for each potential participant. The following will exclude individuals from participating based on their psychiatric or psychological evaluation: * Individua