NCT06341413 Sleep and Emotion Processing in Adolescent Post-traumatic Stress Disorder
| NCT ID | NCT06341413 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Wisconsin, Madison |
| Condition | Post Traumatic Stress Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 180 participants |
| Start Date | 2024-07-16 |
| Primary Completion | 2028-10-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 180 participants in total. It began in 2024-07-16 with a primary completion date of 2028-10-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this clinical trial is to characterize the role of sleep, emotion processing, and daily affect in post-traumatic stress disorder (PTSD) and whether improving sleep quality using slow wave activity enhancement will impact next-day affect in youth. Participants will attend 4 study visits: * A clinical and trauma assessment visit * A testing day that may include cognitive testing, surveys, and an MRI. * An overnight sleep study following one week of at-home sleep recordings with the device in the sham condition * An overnight sleep study following one week of at-home sleep recordings with the device in the sleep enhancement condition
Eligibility Criteria
Inclusion Criteria: All participants must meet all of the following criteria: * Aged 14-18 years old, inclusive * Must agree to inform the investigators within 48 hours of any emergent medical conditions and procedures * Able to lie still on their back for up to 1 hour * Must not be pregnant * Must agree not to participate in any other interventional clinical trials during the duration of the study * Must be willing to comply with all study procedures * Agree to have study visits video and/or audio recorded, including consent visit, clinical assessments (for staff training) and in-laboratory sleep visits (recording deleted within one month of study visit). * A primary parent or guardian is willing participate in the study and to provide informed consent * Are fluent in or predominantly speaking and reading in English In addition, PTSD and TEC youth must satisfy the following criteria: \- Must have a history of at least one traumatic event of any type, as defined by the DSM-V. This may include exposure to physical or sexual abuse, witnessing violence against loved ones or friends, traumatic accidents, natural disasters, death of a close family member etc. Additional criteria for PTSD youth: \- At baseline, meet threshold for DSM-5 criteria for current severe PTSD, as determined by the semi-structured clinical interview (KSADS). Exclusion Criteria: * Caregiver or adolescent is unwilling or unable to give adequate informed consent. * Are likely, in the investigator's opinion and via observation during the screening and clinical assessment period, to be re-exposed to their index trauma or other significant trauma, lack social support, or lack a stable living situation during study participation. * Any finding(s), based on the screening process, that the PI feels would make the study unsuitable for the participant. * Participation in the last 30 days in a clinical study involving an investigational drug * MRI contraindication * Claustrophobia or inability lie still in the scanner after practice MRI sessions. * Any participant presenting current serious suicide risk, as determined through the KSADS, responses to C-SSRS, and/or clinical judgment of the investigator, will be excluded; however, history of suicide attempts is not an exclusion. Would present a serious risk to others as established through clinical interview and contact with treating physician. * Neurodevelopmental disorders such as autism spectrum disorder * Intellectual Disability (IQ less than 70, per self-report) * Currently impaired by any medical condition that would prevent study participation * Traumatic brain injury with ongoing symptoms, including headache, visual disturbances, and/or impairments in concentration. * Neurological disorder(s) such as seizures, epilepsy, or brain tumors (Tourette's disorder, as diagnosed in the KSADS, is not exclusionary for TEC/PTSD youth) * Current use of medications or other drugs (i.e., alcohol) in a manner that may interfere with sleep. * Possible pregnancy Exclusions for Typically developing youth: * No history of or current psychopathology, as defined in the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS), with exception of past specific phobia and past, resolved episodes of depressive or anxiety disorders. Provided that: * The episode is not current (i.e. does not meet current criteria as assessed by the KSADS), * The participant is not currently receiving psychiatric treatment (medication or psychotherapy) for mood/anxiety, and * There is no current serious suicide risk (per KSADS/C-SSRS). * Current diagnosis of a sleep disorder (self-report). * Any history of any traumatic experience as defined by the DSM-V, including IPV exposure, neglect, or emotional abuse etc. PTSD Youth: \- Current diagnosis of or history of psychotic disorder, bipolar disorder, or autism spectrum disorder diagnosed by the KSADS interview. No other co-morbid disorders are exclusionary. TEC Youth: \- A current diagnosis of PTSD or a current diagnosis of or history of psychotic disorder, bipolar disorder, or autism spectrum disorder diagnosed by the KSADS interview.
Contact & Investigator
Stephanie Jones, MD, PhD
PRINCIPAL INVESTIGATOR
University of Wisconsin, Madison
Frequently Asked Questions
Who can join the NCT06341413 clinical trial?
This trial is open to participants of all sexes, aged 14 Years or older, up to 18 Years, studying Post Traumatic Stress Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06341413 currently recruiting?
Yes, NCT06341413 is actively recruiting participants. Contact the research team at sheyn@wisc.edu for enrollment information.
Where is the NCT06341413 trial being conducted?
This trial is being conducted at Madison, United States.
Who is sponsoring the NCT06341413 clinical trial?
NCT06341413 is sponsored by University of Wisconsin, Madison. The principal investigator is Stephanie Jones, MD, PhD at University of Wisconsin, Madison. The trial plans to enroll 180 participants.