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Recruiting NCT03584204

Skeletal Muscle Parameters of Liver Cirrhosis in Non-invasive Imaging and Outcome

◆ AI Clinical Summary

This study examines how skeletal muscle measurements on imaging scans can predict outcomes in patients with advanced liver cirrhosis, particularly those who have undergone a TIPS procedure. Researchers will compare different muscle measurement techniques to determine which is most useful for predicting patient prognosis.

Key Objective: The trial aims to identify which muscle imaging measurements best predict survival and complications in advanced liver cirrhosis patients.

Who to Consider: Patients with decompensated liver cirrhosis, especially those who have had or are considering a TIPS procedure, should consider participating.

Trial Parameters

Condition Liver Cirrhosis
Sponsor University Hospital, Bonn
Study Type OBSERVATIONAL
Phase N/A
Enrollment 400
Sex ALL
Min Age 18 Years
Max Age 80 Years
Start Date 2018-01-01
Completion 2025-07-31
Interventions
imaging

Brief Summary

The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.

Eligibility Criteria

Inclusion Criteria: * liver cirrhosis of any etiology * CT scan available Exclusion Criteria: * HCC or any malignant disease

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