NCT07432477 Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
| NCT ID | NCT07432477 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Ondokuz Mayıs University |
| Condition | Atelectasis, Postoperative |
| Study Type | INTERVENTIONAL |
| Enrollment | 52 participants |
| Start Date | 2026-02-15 |
| Primary Completion | 2027-02-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 52 participants in total. It began in 2026-02-15 with a primary completion date of 2027-02-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.
Eligibility Criteria
Inclusion Criteria: * Age 18-80 years * ASA (American Society of Anesthesiologists) II-IV * Patients undergoing elective cardiac surgery (coronary artery bypass grafting, mitral valve replacement, aortic valve replacement) Exclusion Criteria: * Emergency surgery * Presence of perioperative arrhythmia * \<35% left ventricular ejection fraction * \>50 mmHg systolic pulmonary artery pressure * Known chronic obstructive pulmonary disease or interstitial lung disease * Pneumothorax * Mean arterial pressure \<60 mmHg during recruitment maneuver * New York Heart Association (NYHA) class III-IV heart failure * Advanced cardiomyopathy or severe mitral regurgitation * Cross-clamp time longer than 2 hours * Requirement for high-dose inotropic or vasopressor support * Patients who cannot be extubated after postoperative 24 hours
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07432477 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 80 Years, studying Atelectasis, Postoperative. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07432477 currently recruiting?
Yes, NCT07432477 is actively recruiting participants. Contact the research team at burhandost@hotmail.com for enrollment information.
Where is the NCT07432477 trial being conducted?
This trial is being conducted at Samsun, Turkey (Türkiye).
Who is sponsoring the NCT07432477 clinical trial?
NCT07432477 is sponsored by Ondokuz Mayıs University. The trial plans to enroll 52 participants.