NCT07110207 Single-centre Descriptive Study of Taste in Frontotemporal Lobar Degeneration Through the Analysis of Taste Evoked Potentials
| NCT ID | NCT07110207 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Condition | Frontotemporal Lobar Degeneration (FTLD) |
| Study Type | INTERVENTIONAL |
| Enrollment | 20 participants |
| Start Date | 2025-08-18 |
| Primary Completion | 2027-08 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 20 participants in total. It began in 2025-08-18 with a primary completion date of 2027-08.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The FRONTAL-PEG study focuses on taste perception in frontotemporal lobar degeneration (FTLD). This neurodegenerative disease, characterised by progressive loss of nerve cells, is the second leading cause of dementia after Alzheimer's disease. Patients with FTLD often experience olfactory disorders (= sense of smell) and eating disorders: increased appetite, increased food intake and excessive consumption of sugary foods and snacking. This often leads to excessive weight gain. These eating disorders are still poorly understood at present. In this context, we hypothesise that an alteration in the gustatory pathway - i.e. the way in which the brain perceives taste - could contribute to the eating disorders frequently observed in frontotemporal dementia (FTD), particularly in the marked attraction to sweet foods. We therefore wish to objectively evaluate the taste response to a sweet solution (sucrose) in patients with FTLD, using taste evoked potentials (TEPs). Taste evoked potentials are a reliable and reproducible technique for assessing brain activity in response to taste stimulation. One of their advantages is that they are non-invasive. This study will document, for the first time in this disease, the characteristics of cortical (brain) processing of taste information. The FRONTAL-PEG study is an interventional, regional, single-centre study conducted at the Dijon University Hospital, in collaboration with the CMRR (Memory, Resources and Research Centre) and the CSGA (Centre for Taste and Food Sciences). All investigations are carried out at the CSGA (building adjacent to the Dijon University Hospital), with the exception of blood tests, which are carried out at the Dijon University Hospital. The total duration of participation in the study is one morning. No follow-up is planned at the end of the study.
Eligibility Criteria
Inclusion Criteria: * Person who has given their free and informed consent * Person of legal age * Fasting \> 2 hours before PEG measurement * Body Mass Index (BMI) \< 30 kg/m² (according to medical record data) * DLFT: diagnostic criteria for established or probable DLFT Exclusion Criteria: * Persons not affiliated with or not covered by a social security scheme * Persons subject to legal protection measures (guardianship, trusteeship) * Persons subject to judicial protection measures * Pregnant women, women in labour or breastfeeding women * MMSE score \< 15 and/or MoCA score \< 10 * Known COVID-19 infection within 6 months prior to inclusion * Active smokers (\> 4 cigarettes per day on a regular basis) * Subject with a pacemaker (contraindication for bioelectrical impedance analysis) * Subject with diabetes (type 1 or type 2) * Taking medication (during the study) that interferes with taste
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07110207 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Frontotemporal Lobar Degeneration (FTLD). Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07110207 currently recruiting?
Yes, NCT07110207 is actively recruiting participants. Contact the research team at agnes.jacquin-piques@chu-dijon.fr for enrollment information.
Where is the NCT07110207 trial being conducted?
This trial is being conducted at Dijon, France.
Who is sponsoring the NCT07110207 clinical trial?
NCT07110207 is sponsored by Centre Hospitalier Universitaire Dijon. The trial plans to enroll 20 participants.