NCT04897516 Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease
| NCT ID | NCT04897516 |
| Status | Recruiting |
| Phase | Phase 3 |
| Sponsor | Laboratorio Elea Phoenix S.A. |
| Condition | Chagas Disease |
| Study Type | INTERVENTIONAL |
| Enrollment | 300 participants |
| Start Date | 2021-07-28 |
| Primary Completion | 2026-06-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
Phase 3 trials are large pivotal studies comparing the treatment to current standard of care or placebo. Your participation directly contributes to the evidence needed for regulatory approval.
This trial targets 300 participants in total. It began in 2021-07-28 with a primary completion date of 2026-06-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Chagas disease, a parasitic infection caused by Trypanosoma cruzi, is endemic in much of Latin America and affects people throughout the world. Currently treatment with the only two drugs effective against the infection, benznidazole and nifurtimox, has significant limitations including frequent adverse effects in adult patients. However, timely treatment is key to achieving global objectives of controlling the disease. The standard treatment has a long duration (60 days). NuestroBen will test the hypothesis that shorter treatment regimens of 14 days and 28 days will be non-inferior to the standard 60-day treatment while improving the safety profile.
Eligibility Criteria
Inclusion criteria (Subjects must meet ALL the inclusion requirements listed below to enter the study): * Signed informed consent form; * Between ≥18 and ≤60 years of age; * Weight ≥ 50 kg to ≤ 95 kg; * Confirmation of the diagnosis of T. cruzi infection by conventional serology (a minimum of two tests must be reactive); * Serial qualitative PCR (one blood sample divided in three DNA extractions, at least one of which must be positive); * Women of childbearing potential must have a negative pregnancy result at the time of inclusion, must not be breast-feeding, and must use a highly effective method of contraception during study treatment and until 30 days after the last dose of study treatment or demonstrate permanent sterilization; * Ability to comply with all exams and specific protocol visits; * Having a permanent address; * ECG criteria: (Heart rate: 50 -100 bpm or isolate sinus bradycardia from 41 to 59 beats/min; QRS ≤120 msec, and QTc ≥ 350 msec and ≤ 450 msec) at screening) or following findings belonging to non-severe chagasic cardiomyopathy: uncomplete right bundle branch block, Left anterior fascicular block, First-degree atrioventricular block, Low voltage. The abnormalities included are not exclusionary; * Normal or minimal structural changes in echocardiogram (left ventricular diastolic diameter (LVDD) \<= 55 mm, diastolic dysfunction, absence of Microaneurysm or tip aneurysm, absence of hypo or generalized akinesia, absence of Systolic dysfunction (low fractional shortening and ejection fraction), and/or absence of mural thrombus); * Not presenting signs or symptoms of moderate- severe chronic cardiac and/or digestive forms of Chagas disease (criteria detailed in Study Manual and specific SOP); * No prior history of mental disorders or suicidal tendencies; * Not suffering from known acute or chronic illnesses at the moment of selection for the study that, in the Investigator's discretion, may interfere with the evaluation of the efficacy or safety of the investigational product (such as acute infections, immunosuppressive conditions, or liver or kidney diseases that have required treatment); * Not having received a formal indication not to take BZN (contraindication, according to the Summary of Product Characteristics - SmPC); * No prior history of hypersensitivity, allergy, or serious adverse reactions to any of the nitroimidazole compounds (including BNZ) and/or its components/excipients; * Have not previously undergone antiparasitic treatment for T. cruzi infection; * No prior history of drug abuse or alcoholism; * Not suffering from any disease or condition that prevents subjects from consuming oral medication. Exclusion criteria (The presence of any of the items below will exclude subjects from inclusion in the study): * Subject pregnant or intending to become pregnant during treatment and within 30 days of the last dose of study treatment; * Signs or symptoms of the established (moderate- severe) chronic cardiac and/or digestive form of Chagas disease, or any ECG/ echocardiographic findings not included at Inclusion criteria; * History of cardiomyopathy, heart failure, or severe ventricular arrhythmia; * History of digestive surgery potentially related to Chagas Disease or megacolon / mega-esophagus; * Acute or chronic disease that, in the Investigator's discretion, may interfere with the evaluation of the efficacy or safety of the investigational product (such as acute infection, history of immunosuppressive conditions, or liver or kidney disease that has required treatment); * Laboratory test values that are considered clinically significant or outside the allowable values, per Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 grade 1; * Disease or clinical condition that prevents subjects from consuming oral medication; * Subjects with a contraindication (known hypersensitivity) to any of the nitroimidazole compounds, e.g. metronidazole; * Subjects with a history of allergy (serious or not), allergic rash, asthma, intolerance, sensitivity or photosensitivity; * Concomitant use and/or consumption of allopurinol, antimicrobial and antiparasitic agents, herbal medicines, dietary supplements and energy drinks; * Scheduled surgery that may interfere with the conduct of the trial and/or with the treatment evaluation; * Inability to attend study visits, comply with treatment, and cooperate with study procedures; * Previous participation in a trial for the evaluation of the treatment of T. cruzi infection; * Simultaneous participation in another trial or within 3 months prior to screening for this trial (in accordance with national regulations). * Subjects suffering from a serious medical or psychiatric illness that increases the risk associated with study participation or that interferes with the interpretation of study results should not be included.
Contact & Investigator
María Jesús Pinazo, MD
STUDY DIRECTOR
Drugs for Neglected Diseases
Frequently Asked Questions
Who can join the NCT04897516 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Chagas Disease. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
What phase is the NCT04897516 trial and what does that mean for participants?
Phase 3 trials are large-scale studies comparing the new treatment to existing standards of care or a placebo. They provide the evidence needed for regulatory approval. This trial targets 300 participants.
Is NCT04897516 currently recruiting?
Yes, NCT04897516 is actively recruiting participants. Contact the research team at carola.lombas@elea.com for enrollment information.
Where is the NCT04897516 trial being conducted?
This trial is being conducted at Buenos Aires, Argentina, Buenos Aires, Argentina, Buenos Aires, Argentina, Buenos Aires, Argentina and 2 additional locations.
Who is sponsoring the NCT04897516 clinical trial?
NCT04897516 is sponsored by Laboratorio Elea Phoenix S.A.. The principal investigator is María Jesús Pinazo, MD at Drugs for Neglected Diseases. The trial plans to enroll 300 participants.