NCT06450301 Senescent Endometrial Cells in Patients with Thin Endometrial Lining
| NCT ID | NCT06450301 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Trio Fertility |
| Condition | Asherman's Syndrome |
| Study Type | OBSERVATIONAL |
| Enrollment | 100 participants |
| Start Date | 2024-09-11 |
| Primary Completion | 2027-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 100 participants in total. It began in 2024-09-11 with a primary completion date of 2027-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives. The main question it aims to answer is: Are there any senescent cells present in thin endometrial lining? During the luteal phase of the cycle, participants will will undergo: * Gynecologic US to measure the endometrial lining thickness and pattern. * Endometrial biopsy with Pipelle catheter
Eligibility Criteria
Inclusion Criteria: * Age 18-39 * BMI - up to 35 * Thin endometrium after OCP use * Asherman's syndrome * Women already undergoing endometrial biopsy for infertility testing (eg. EMMA testing) * Women with archived endometrial biopsy samples Exclusion Criteria: * Women with systemic disease (Rheumatic disease, DM) * Women with coagulopathies * Women with active pelvic inflammatory process * Uterine anomalies * Pregnant women * Any hormonal contraception use or IUD
Frequently Asked Questions
Who can join the NCT06450301 clinical trial?
This trial is open to female participants only, aged 18 Years or older, up to 39 Years, studying Asherman's Syndrome. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06450301 currently recruiting?
Yes, NCT06450301 is actively recruiting participants. Visit ClinicalTrials.gov or contact Trio Fertility to inquire about joining.
Where is the NCT06450301 trial being conducted?
This trial is being conducted at Toronto, Canada.
Who is sponsoring the NCT06450301 clinical trial?
NCT06450301 is sponsored by Trio Fertility. The trial plans to enroll 100 participants.