NCT05884983 Screening Effect of Dual-energy CT Combined With Nasopharyngeal Endoscopy for Screening Nasopharyngeal Carcinoma
| NCT ID | NCT05884983 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Zhongshan People's Hospital, Guangdong, China |
| Condition | Nasopharyngeal Carcinoma |
| Study Type | OBSERVATIONAL |
| Enrollment | 12,000 participants |
| Start Date | 2023-02-01 |
| Primary Completion | 2026-12-31 |
Trial Parameters
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
Brief Summary
All participants will be tested for EBV-related biomarkers, including EBNA1-IgA, VCA-IgA, and BNLF2b total antibody (P85-Ab), and participants with high serologic risk will be selected based on serologic test results, and dual-energy CT will be performed first for high-risk screening subjects, and dual-energy CT will be performed first for the high-risk group to record dual-energy CT examinations of those suspected of nasopharyngeal carcinoma, and then endoscopy was performed on the high-risk group to record those suspected of nasopharyngeal carcinoma under endoscopy, and finally biopsies were taken for positive lesion sites indicated by dual-energy CT and suspicious lesion sites found by endoscopy to clarify the diagnosis.
Eligibility Criteria
Inclusion Criteria: * Subject residents in Zhongshan City * Subject has no medical record of nasopharyngeal carcinoma * Subject is able to comprehend, sign, and date the written informed consent document to participate in the study * Subject has psychical condition and well consciousness, and also accept and cooperate with the follow-up of this study Exclusion Criteria: * Subject has heavy cardiovascular, liver or kidney disease * Subject has contraindications to nasopharyngeal endoscopy * Subject has contrast media allergy