NCT07389148 Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
| NCT ID | NCT07389148 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Lokman Hekim University |
| Condition | Molar Incisor Hypomineralization |
| Study Type | OBSERVATIONAL |
| Enrollment | 90 participants |
| Start Date | 2026-01-26 |
| Primary Completion | 2026-03-26 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 90 participants in total. It began in 2026-01-26 with a primary completion date of 2026-03-26.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment. These problems can increase dental anxiety and lead to physiological stress responses during dental visits. The purpose of this observational study is to evaluate physiological stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, and to compare these findings with those of children without MIH. A total of 90 children aged 8 to 12 years will participate in the study, including 45 children diagnosed with MIH and 45 healthy control participants. Participation involves no treatment or intervention beyond a routine clinical dental examination. Heart rate and oxygen saturation will be measured during the dental visit, and saliva samples will be collected immediately after the examination using a non-invasive method to assess cortisol levels. The results of this study may contribute to a better understanding of stress responses in children with MIH and support the development of more individualized and anxiety-sensitive dental care approaches.
Eligibility Criteria
Inclusion Criteria: * Children aged between 8 and 12 years. * Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH. * Ability to cooperate sufficiently to complete the clinical dental examination and study procedures. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Presence of systemic, hormonal, or metabolic diseases. * Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers). * History of systemic conditions that may influence stress response. * Refusal of participation by the child or parent/legal guardian.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07389148 clinical trial?
This trial is open to participants of all sexes, aged 8 Years or older, up to 12 Years, studying Molar Incisor Hypomineralization. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07389148 currently recruiting?
Yes, NCT07389148 is actively recruiting participants. Contact the research team at hamide.comert@lokmanhekim.edu.tr for enrollment information.
Where is the NCT07389148 trial being conducted?
This trial is being conducted at Ankara, Turkey (Türkiye).
Who is sponsoring the NCT07389148 clinical trial?
NCT07389148 is sponsored by Lokman Hekim University. The trial plans to enroll 90 participants.