NCT07142122 Safety Comparison of Total Laparoscopic Proximal Gastrectomy With or Without Preservation of the Celiac Branch of the Vagus Nerve for Early Upper Gastric Cancer: A Randomized Controlled Clinical Trial
| NCT ID | NCT07142122 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Fujian Cancer Hospital |
| Condition | Gastric Cancer |
| Study Type | INTERVENTIONAL |
| Enrollment | 76 participants |
| Start Date | 2025-01-01 |
| Primary Completion | 2029-01-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 76 participants in total. It began in 2025-01-01 with a primary completion date of 2029-01-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This prospective, single-center, randomized, controlled, non-inferiority clinical trial aims to compare the safety and postoperative quality of life of early upper gastric cancer patients undergoing total laparoscopic proximal gastrectomy (TLPG) with preservation of both the hepatic and celiac branches of the vagus nerve versus preservation of the hepatic branch only. The primary endpoint is gastric emptying half-time of solid food at 6 months after surgery. Secondary outcomes include incidence of reflux esophagitis, quality of life scores (EORTC QLQ-C30/STO22), number and positivity rate of lymph nodes retrieved, and 3-year disease-free survival. The study will provide evidence for optimizing minimally invasive surgical strategies for early upper gastric cancer.
Eligibility Criteria
Inclusion Criteria: 1. Age 18-75 years. 2. Histologically confirmed gastric adenocarcinoma or esophagogastric junction adenocarcinoma (papillary, tubular, mucinous, poorly cohesive including signet-ring cell carcinoma, or mixed type). 3. Primary tumor located in the upper third of the stomach, or esophagogastric junction cancer with tumor size ≤4 cm. 4. Clinical stage cT1bN0M0 without lymph node metastasis. 5. BMI \<30 kg/m². 6. No history of upper abdominal surgery (except laparoscopic cholecystectomy). 7. No prior chemotherapy, radiotherapy, targeted therapy, or immunotherapy. 8. ECOG performance status 0-1. 9. ASA class I-III. 10. Adequate organ function. 11. Signed informed consent. Exclusion Criteria: 1. Pregnancy or breastfeeding. 2. Other malignancies within 5 years. 3. Active infection requiring systemic therapy or fever ≥38°C preoperatively. 4. Severe psychiatric illness. 5. Severe respiratory disease. 6. Severe hepatic or renal dysfunction. 7. Unstable angina or myocardial infarction within 6 months. 8. Stroke or intracranial hemorrhage within 6 months. 9. Long-term systemic glucocorticoid therapy within 1 month (local use excluded). 10. Complications of gastric cancer (bleeding, perforation, obstruction). 11. Participation in another clinical study within 6 months. Exclusion During Study (Removal Criteria): R0 resection not achieved, change of procedure to total gastrectomy or PPG, combined surgery for other diseases, severe perioperative complications, emergency surgery required, patient withdrawal of consent, or protocol violation.
Contact & Investigator
Frequently Asked Questions
Who can join the NCT07142122 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 75 Years, studying Gastric Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07142122 currently recruiting?
Yes, NCT07142122 is actively recruiting participants. Contact the research team at flyingengel@sina.com for enrollment information.
Where is the NCT07142122 trial being conducted?
This trial is being conducted at Fuzhou, China.
Who is sponsoring the NCT07142122 clinical trial?
NCT07142122 is sponsored by Fujian Cancer Hospital. The trial plans to enroll 76 participants.
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