NCT04565795 Safety and Device Performance of the Uriprene® Degradable Temporary Ureteral Stent Following Uncomplicated Ureteroscopy
| NCT ID | NCT04565795 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Adva-Tec |
| Condition | Ureteral Diseases |
| Study Type | INTERVENTIONAL |
| Enrollment | 87 participants |
| Start Date | 2022-07-01 |
| Primary Completion | 2027-03 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 87 participants in total. It began in 2022-07-01 with a primary completion date of 2027-03.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
A prospective, multi-center, non-randomized trial to demonstrate safety and device performance of the ADVA-Tec Uriprene® Degradable Temporary Ureteral Stent.
Eligibility Criteria
Inclusion Criteria: 1. Subjects who are \>21, \<80 years of age; inclusive of males and females. 2. Subjects with unilateral ureteral or renal stones who have undergone a successful, uncomplicated ureteroscopy (UURS). 3. Subjects with asymptomatic, contralateral renal stones in sizes \<4mm WHICH ARE NOT IN THE RENAL PELVIS OR URETER and who have had uncomplicated ureteroscopy (UURS) can be included. If, during the course of treatment of the target ureter with the Uriprene stent the patient's asymptomatic stone becomes symptomatic and requires treatment, the patient can only be managed with standard of care treatment including the use of an approved ureteral stent, if necessary. 4. Subjects with a height and body size able to accommodate a 20, 22, 24, 26, 28, or 30 mm long ureteral stent, as judged by the Investigator. 5. Subjects with the ability to understand the requirements of the study, who have provided written informed consent, and are willing to undergo all follow-up assessments according to the specified schedule. Exclusion Criteria: 1. Subjects with a history of an anatomical abnormality of the urinary tract. 2. Presence of ureteral fistula. 3. Presence of urothelial cancer, ureteral tumor, or renal tumor. 4. Presence of extrinsic compression of the ureter. 5. Presence of ureteral blockage or stricture. 6. Bladder outlet obstruction or neurogenic bladder. 7. Subjects with known/diagnosed overactive bladder (OAB). 8. Subjects with known/diagnosed urge urinary incontinence (UUI). 9. Subjects with a known, active upper or lower urinary tract infection at the time of stent insertion. 10. Subjects with creatinine level of ˃2.5 mg/dl. 11. Pregnant or lactating women, or women of childbearing potential who do not employ a reliable method of contraception as judged by the Investigator, and/or are not willing to use reliable contraception for the duration of study participation. 12. Impacted ureteral stones still in place and/or incomplete stone fragmentation. 13. Ureteral perforation. 14. Staghorn calculi. 15. Subjects with a solitary kidney. 16. History of bleeding diathesis or currently taking blood thinners such as warfarin (anti- platelet agents are allowed). 17. Contrast allergy that cannot be adequately pre-treated. 18. Subject has known severe psychiatric disorder, substance abuse, or other reason for being unable to follow trial follow-up instructions or unable to reliably complete patient questionnaires. 19. Any condition, in the opinion of the investigator, that would deem a subject as ineligible for treatment with the Uriprene® Stent. 20. Subject has a known significant concomitant illness with a life expectancy of \<1 year. 21. Subject is known to be currently enrolled in another investigational trial.
Contact & Investigator
Mitchell Humphreys, MD
PRINCIPAL INVESTIGATOR
Mayo Clinic
Frequently Asked Questions
Who can join the NCT04565795 clinical trial?
This trial is open to participants of all sexes, aged 21 Years or older, up to 80 Years, studying Ureteral Diseases. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT04565795 currently recruiting?
Yes, NCT04565795 is actively recruiting participants. Contact the research team at jcartledge@adva-tec.com for enrollment information.
Where is the NCT04565795 trial being conducted?
This trial is being conducted at Phoenix, United States, Los Angeles, United States, Gainesville, United States, Columbus, United States.
Who is sponsoring the NCT04565795 clinical trial?
NCT04565795 is sponsored by Adva-Tec. The principal investigator is Mitchell Humphreys, MD at Mayo Clinic. The trial plans to enroll 87 participants.