NCT07588113 rTMS Induced Reduction in M1 Excitability
| NCT ID | NCT07588113 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Indiana University |
| Condition | Cortical Excitability |
| Study Type | INTERVENTIONAL |
| Enrollment | 32 participants |
| Start Date | 2026-04-23 |
| Primary Completion | 2027-04-23 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 32 participants in total. It began in 2026-04-23 with a primary completion date of 2027-04-23.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
When learning a new skill, much of the improvement comes from small alterations the brain makes with each repetition during practice, but this isn't the only time that improvements are made during the learning process. Individuals also get better at the motor skills during the time between practices, through a process called "consolidation." It is known that an area of the brain called the primary motor cortex is involved in learning during active practice, but the investigators want to study if the primary motor cortex is important for consolidation. The investigators will examine how lowering the activity in this brain region affects your ability to consolidate learning to play a song on the videogame Guitar Hero.
Eligibility Criteria
Inclusion Criteria: * Between ages 18 and 45 years old (to avoid any changes in the developing brain, or with aging). * Answer 'no' to questions 2 through 17 on the brain stimulation questionnaire as these factors can increase likelihood of adverse events with brain stimulation. * No neurological damage, disease, or dysfunction (nerve damage, chronic pain disorders, diabetic neuropathy, epilepsy) that affect the upper limbs and limit the ability to complete the study, and/or compromise the objectives of the study * No significant visual impairment that would prevent them from playing a video game. Exclusion Criteria: * Currently prescribed and taking stimulant medication (Adderall, Ritalin, Vyvanse, etc.) * Consumption of over-the-counter stimulants such as caffeine or nicotine (coffee, soda, supplements, energy drinks, tobacco products, or other nicotine containing products such as gum, vape pens, etc...) 12 hours prior to entering the lab on the day of testing as this can directly affect cortical excitability. If a subject takes any of these substances 12 hours prior to the study visit they will be asked to reschedule for a later date. * Have played a real stringed instrument in the last 12 months (e.g. guitar, bass, violin) * Have played the videogame "Guitar Hero" on a traditional guitar controller in the last 12 months.
Contact & Investigator
Zachary Riley
PRINCIPAL INVESTIGATOR
Professor
Frequently Asked Questions
Who can join the NCT07588113 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 45 Years, studying Cortical Excitability. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT07588113 currently recruiting?
Yes, NCT07588113 is actively recruiting participants. Contact the research team at zariley@iu.edu for enrollment information.
Where is the NCT07588113 trial being conducted?
This trial is being conducted at Indianapolis, United States.
Who is sponsoring the NCT07588113 clinical trial?
NCT07588113 is sponsored by Indiana University. The principal investigator is Zachary Riley at Professor. The trial plans to enroll 32 participants.