NCT05149534 rTMS-augmented Written Exposure Therapy for PTSD
| NCT ID | NCT05149534 |
| Status | Recruiting |
| Phase | — |
| Sponsor | VA Office of Research and Development |
| Condition | Post Traumatic Stress Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 98 participants |
| Start Date | 2022-01-03 |
| Primary Completion | 2027-01-29 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 98 participants in total. It began in 2022-01-03 with a primary completion date of 2027-01-29.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.
Eligibility Criteria
Inclusion Criteria: -All veterans are eligible to be included in the study if they meet all the following criteria: * veteran; * English-speaking and able to provide written informed consent; * diagnosed with PTSD; * between the ages of 18 and 60 years. Participants over age 60 will not be included, as aging is known to impact brain structure, and thus the potential accuracy of the rTMS target, independently of PTSD. Exclusion Criteria: * Individuals with history of seizures or other serious neurological history including acquired, developmental or degenerative neurologic illness, identified through medical chart review, will be excluded due to potential lowered threshold for seizures during rTMS stimulation. * The effects of rTMS are unknown on fetal development, therefore, women who are pregnant will be excluded. * Participants will also be screened and excluded if any of the following are met: * current psychosis including psychotic disorder, * bipolar disorder, * schizophrenia; or another severe cognitive or psychiatric disorder; * positive screen for current suicidal intent and plan \[with a score of 2 or 3 on BDI-2 item 9\]; * current substance use disorder; or substance use in the last 12 hours before the rTMS session. * The investigators note that PTSD is often comorbid with traumatic brain injury (TBI) in military veterans who were deployed to a war zone. The investigators will use the Department of Defense and Veterans Affairs consensus-based classification of TBI severity for classification of TBI. * Participants with moderate or severe TBI will be excluded. * Participants with mild traumatic brain injury (mTBI) or concussion will be enrolled. This will enhance the ecological validity of the study. * Participants with cognitive impairment as evidenced by a Montreal Cognitive Screen (MoCA) less than 23/30 or estimated baseline intellectual ability of a standard score of less than 80 on a word reading test will be excluded due to potential neurocognitive differences. * Participants on psychotropic medications will not be excluded, but participants will be required to be stable on their medication for at least four weeks prior to beginning the study and throughout the time of study. * Participants enrolled in long term, supportive psychotherapy (i.e. not an evidence-based psychotherapy (EBP)) may continue to be involved in their treatment throughout the study. However, participants involved in a concurrent EBPs will be excluded. Participants will be asked to disclose whether they chose to participate in an EBP during the course of the treatment or followup phases of the study.
Contact & Investigator
Crystal M Lantrip
PRINCIPAL INVESTIGATOR
Central Texas Veterans Health Care System, Temple, TX
Frequently Asked Questions
Who can join the NCT05149534 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 60 Years, studying Post Traumatic Stress Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05149534 currently recruiting?
Yes, NCT05149534 is actively recruiting participants. Contact the research team at crystal.lantrip@va.gov for enrollment information.
Where is the NCT05149534 trial being conducted?
This trial is being conducted at Temple, United States.
Who is sponsoring the NCT05149534 clinical trial?
NCT05149534 is sponsored by VA Office of Research and Development. The principal investigator is Crystal M Lantrip at Central Texas Veterans Health Care System, Temple, TX. The trial plans to enroll 98 participants.