Role of Kefir Mouth Wash in Oral Health Status Amelioration
Trial Parameters
Brief Summary
The present research aims to evaluate the efficiency of kefir mouthwash in enhancing oral health status by employing an in vivo experimental approach. Specifically, the study will assess how kefir mouthwash influences key oral health indicators, including gingival inflammation, plaque development, oral hygiene status, and halitosis. The study will be conducted over a 28-day period, with follow-up assessments every 14 days. The study will include systemically healthy adults with moderate gingivitis. Clinical parameters such as the Gingival Index (GI), Plaque Index (PI), and Simplified Oral Hygiene Index (OHI-S) will be measured, along with inflammatory biomarkers, including Interleukin-1β (IL-1β) and Interleukin-10 (IL-10). Halitosis will be evaluated using a Hali meter device. All of these will be measured at base line and day 14 and day 28 end of the study. Chlorhexidine 0.12% will be used as a comparative control to evaluate the efficacy of kefir mouthwash in improving oral health. This research intends to provide scientific evidence supporting the use of kefir as a probiotic-based mouthwash, offering a natural alternative to chemical mouthwashes and potentially reducing the negative consequences commonly associated with their use.
Eligibility Criteria
Inclusion Criteria: * Age range 18-28 years. * Systemically healthy people without a history of chronic illness. * Those suffering with moderate gingivitis. * Not using any antibiotics over three months Exclusion Criteria: * History of systemic diseases. * Pregnant, lactating females. * History of antibiotic therapy in the past 3 months. * History of oral prophylaxis within the last 6 months prior to the study as this can confound the results, making it difficult to determine the real effect of the mouthwash. * Subjects with mouth breathing habits. * Subjects with orthodontic and prosthodontic appliances. * Subjects with deleterious habits such as smoking, because it may affect oral health status, causing periodontal disease, altered oral microbiota, and impaired healing. This can confound the study results, making it difficult to observe the mouthwash effect . * Failure to follow the prescription regimen. * Failure to follow the research protocol.