NCT06148467 Reverse Trigger Phenotypification and Response to Ventilatory Adjustments
| NCT ID | NCT06148467 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Hospital Civil de Guadalajara |
| Condition | Reverse Trigger |
| Study Type | OBSERVATIONAL |
| Enrollment | 130 participants |
| Start Date | 2023-11-17 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
Enter your details for a quick preliminary check. This does not replace medical advice.
What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 130 participants in total. It began in 2023-11-17 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: * Real incidence of RT based on continuous monitoring * The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.
Eligibility Criteria
Inclusion Criteria: * Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023 * Mechanical ventilation Exclusion Criteria: * \<18 years * Tracheostomy status * Pneumothorax * Tube thoracostomy with air leaks
Contact & Investigator
Miguel Ibarra Estrada, MD
PRINCIPAL INVESTIGATOR
Hospital Civil Fray Antonio Alcalde
Frequently Asked Questions
Who can join the NCT06148467 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 90 Years, studying Reverse Trigger. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06148467 currently recruiting?
Yes, NCT06148467 is actively recruiting participants. Contact the research team at drmiguelibarra@hotmail.com for enrollment information.
Where is the NCT06148467 trial being conducted?
This trial is being conducted at Guadalajara, Mexico.
Who is sponsoring the NCT06148467 clinical trial?
NCT06148467 is sponsored by Hospital Civil de Guadalajara. The principal investigator is Miguel Ibarra Estrada, MD at Hospital Civil Fray Antonio Alcalde. The trial plans to enroll 130 participants.