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Recruiting NCT05706558

NCT05706558 Retrospective Review of Esophageal Cancer at MSKCC

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Clinical Trial Summary
NCT ID NCT05706558
Status Recruiting
Phase
Sponsor Memorial Sloan Kettering Cancer Center
Condition Esophageal Cancer
Study Type OBSERVATIONAL
Enrollment 4,000 participants
Start Date 2016-12-13
Primary Completion 2027-02

Eligibility & Interventions

Sex All sexes
Min Age 18 Years
Max Age N/A
Study Type OBSERVATIONAL
Interventions
Esophagectomy

Eligibility Fast-Check

Enter your details for a quick preliminary check. This does not replace medical advice.

What to Expect as a Participant

This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.

This trial targets 4,000 participants in total. It began in 2016-12-13 with a primary completion date of 2027-02.

⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.

Brief Summary

Residual tumor at the proximal or distal margin after esophagectomy is a known prognostic factor for poor survival outcomes in patients with esophageal cancer; however, the significance of the circumferential resection margin (CRM) remains controversial. In this study, the investigators sought to evaluate the prognostic significance of the CRM in patients with esophageal cancer undergoing resection.

Eligibility Criteria

Inclusion Criteria: * Histologically confirmed esophageal adenocarcinoma (EAC) or esophageal squamous cell carcinoma (ESCC) undergoing esophagectomy * Pathologic staged T3 tumors (pT3) Exclusion Criteria: * Pathologic staged T0-2 (pT0-2) or T4 tumors (pT4) * Patients with histologic types other than EAC or ESCC, dysplasia or carcinoma in situ without tumor invasion, * Patients undergoing salvage esophagectomy * Evidence of distant metastatic disease * Patients with a positive proximal or distal margin

Contact & Investigator

Central Contact

Daniela Molena, MD

✉ molenad@mskcc.org

📞 212-639-3870

Principal Investigator

Daniela Molena, MD

PRINCIPAL INVESTIGATOR

Memorial Sloan Kettering Cancer Center

Frequently Asked Questions

Who can join the NCT05706558 clinical trial?

This trial is open to participants of all sexes, aged 18 Years or older, studying Esophageal Cancer. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.

Is NCT05706558 currently recruiting?

Yes, NCT05706558 is actively recruiting participants. Contact the research team at molenad@mskcc.org for enrollment information.

Where is the NCT05706558 trial being conducted?

This trial is being conducted at New York, United States.

Who is sponsoring the NCT05706558 clinical trial?

NCT05706558 is sponsored by Memorial Sloan Kettering Cancer Center. The principal investigator is Daniela Molena, MD at Memorial Sloan Kettering Cancer Center. The trial plans to enroll 4,000 participants.

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ClinicalMetric — Independent clinical trial intelligence platform. Not affiliated with NIH, ClinicalTrials.gov, the U.S. FDA, or any pharmaceutical company, hospital, or clinical research organization. Trial data is sourced from ClinicalTrials.gov for informational purposes only and does not constitute medical advice. Do not make any treatment, enrollment, or health decisions based solely on information found here — always consult a qualified healthcare professional. Full Disclaimer  ·  Last Reviewed: April 2026  ·  Data Methodology