NCT05650905 Retinal Neurovascular Coupling in Patients Previously Infected With COVID-19
| NCT ID | NCT05650905 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Medical University of Vienna |
| Condition | COVID-19 |
| Study Type | OBSERVATIONAL |
| Enrollment | 90 participants |
| Start Date | 2021-07-26 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 90 participants in total. It began in 2021-07-26 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
The Study objective is to measure retinal neurovascular coupling and blood flow parameters in patients previously infected with COVID-19, long COVID-19 and healthy age- and sex- matched control subjects
Eligibility Criteria
Inclusion Criteria: Inclusion criteria for healthy subjects * Men and women aged over 18 years * Non-smokers * Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant * No previous history of COVID-19 infection * Negative testing for SARS-CoV-2 seroprevalence using nucleocapsid antibody tests * Negative PCR test for SARS-CoV-2 * Normal ophthalmic findings, ametropy \< 6 Dpt. Inclusion criteria for subjects with history of COVID-19 infection * Men and women aged over 18 years * Non-smokers * History of COVID-19 infection (confirmed by a positive PCR test for SARS-CoV2 in the medical history) within the last 6 months * Positive testing for SARS-CoV-2 seroprevalence using spike protein IgG antibody tests * Negative PCR test for SARS-CoV-2 Inclusion criteria for subjects with long COVID-19 * Men and women aged over 18 years * Non-smokers * History of COVID-19 infection (confirmed by a positive PCR test for SARS-CoV2 in the medical history) * Positive testing for SARS-CoV-2 seroprevalence * Negative PCR test for SARS-CoV-2 * Long Covid according to the latest WHO-Guidelines Exclusion Criteria: Any of the following will exclude a healthy control subject from the study: * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * Presence or history of a severe medical condition as judged by the clinical investigator * Participation in a clinical trial in the 3 weeks preceding the study * Blood donation during the previous three weeks * History or family history of epilepsy * Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator * Best corrected visual acuity \< 0.8 Snellen * Pregnancy, planned pregnancy or lactatin * History of epilepsia Any of the following will exclude a subject with history of COVID-19 infection from the study: * Blood donation during the previous three weeks * History or family history of epilepsy * Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator * Best corrected visual acuity \< 0.8 Snellen * Ametropy \>6 Dpt * Pregnancy, planned pregnancy or lactating * History of epilepsia Any of the following will exclude a subject with long COVID-19 from the study: * Blood donation during the previous three weeks * History or family history of epilepsy * Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator * Best corrected visual acuity \< 0.8 Snellen * Ametropy \>6 Dpt * Pregnancy, planned pregnancy or lactating * History of epilepsia * Diabetes mellitus
Frequently Asked Questions
Who can join the NCT05650905 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying COVID-19. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT05650905 currently recruiting?
Yes, NCT05650905 is actively recruiting participants. Visit ClinicalTrials.gov or contact Medical University of Vienna to inquire about joining.
Where is the NCT05650905 trial being conducted?
This trial is being conducted at Vienna, Austria.
Who is sponsoring the NCT05650905 clinical trial?
NCT05650905 is sponsored by Medical University of Vienna. The trial plans to enroll 90 participants.
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