NCT06575101 Resting Energy Expenditure and Substrate Consumption in Cardiac Arrest Patients Under Target Temperature Management
| NCT ID | NCT06575101 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Tang Ziren |
| Condition | Targeted Temperature Management |
| Study Type | OBSERVATIONAL |
| Enrollment | 40 participants |
| Start Date | 2024-06-01 |
| Primary Completion | 2025-12-31 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
This is an observational study. You will not receive an experimental treatment; researchers will collect data based on your existing condition or standard treatment.
This trial targets 40 participants in total. It began in 2024-06-01 with a primary completion date of 2025-12-31.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study is a single-center, prospective, observational study. According to the sample size formula, an estimated 40 cases should be collected, all of whom are from the emergency intensive care unit. After successful cardiopulmonary resuscitation, the enrolled patients will be transferred to the emergency intensive care unit for further standardized target temperature management (TTM). They will be divided into 33 ° C hypothermia group and 36 ° C hypothermia group according to the patient's core body temperature. The baseline data of the patients will be collected at the beginning. After admission to the hospital, they were fasted within 24 hours to reach the target temperature, and then 20kcal/kg/d parenteral nutrition will be given. At selected time points (T0: the initial time point before TTM; T1: the core temperature was reduced to 33 ° C or 36 ° C; T2-T4: 33 ° C or 36 ° C was maintained for 24h, 48h, 72h; T5: the end of rewarming; Tend: the last REE measurement before discharge or death) , various observation indicators will be collected, including resting energy expenditure (REE), glucose oxidation rate, fat oxidation rate, protein oxidation rate, and metabolism of three major nutrients Proportion. Neurological outcomes were followed up 28 days after onset according to the Cerebral Performance Categories (CPC) score.
Eligibility Criteria
Inclusion Criteria: * Be admitted to the emergency department of Beijing Chao-yang Hospital, Capital Medical University; * Successfully resuscitated, and are unconscious after restoration of spontaneous circulation (ROSC); * Be admitted to the intensive care unit (ICU) for advanced life support such as endotracheal intubation after restoration of spontaneous circulation (ROSC); * Accepted target temperature management (TTM) therapy after restoration of spontaneous circulation (ROSC); Exclusion Criteria: * Age \> 18 years old； * Incomplete clinical data and loss of follow-up; * Traumatic brain injury or cerebrovascular accident revealed by computed tomography (CT)； * Severe metabolic abnormalities are known: cachexia, thyroid dysfunction, and cancer； * Indirect calorimetry measurement is not possible such as sustained oxygen concentration \> 70%； * There were no signs of resuscitation at the time of admission；
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06575101 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, studying Targeted Temperature Management. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06575101 currently recruiting?
Yes, NCT06575101 is actively recruiting participants. Contact the research team at tangziren1970@163.com for enrollment information.
Where is the NCT06575101 trial being conducted?
This trial is being conducted at Beijing, China.
Who is sponsoring the NCT06575101 clinical trial?
NCT06575101 is sponsored by Tang Ziren. The trial plans to enroll 40 participants.