NCT06110897 RESISTance Exercise for Depression Trial
| NCT ID | NCT06110897 |
| Status | Recruiting |
| Phase | — |
| Sponsor | University of Wisconsin, Madison |
| Condition | Major Depressive Disorder |
| Study Type | INTERVENTIONAL |
| Enrollment | 200 participants |
| Start Date | 2024-01-01 |
| Primary Completion | 2028-11-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 200 participants in total. It began in 2024-01-01 with a primary completion date of 2028-11-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.
Eligibility Criteria
Inclusion Criteria: * Be diagnosed with DSM-5 MDD, confirmed via Structured Clinical Interview for DSM-5 (SCID). * Have current depressive symptoms of at least mild severity defined by the Hamilton Rating Scale of Depression 17 greater than or equal to 8 (HAMD; using the GRID-HAMD evaluated by trained, masked raters) * Be ages 18-65 * EITHER not taking any mental health medications or seeking other mental health treatment (e.g., behavioral, psychological) OR be on a stable mental health medication and/or treatment regimen for the past 8 weeks, and intend to maintain that regimen for the duration of the study * Safe to exercise based on physical activity screening questions or physician clearance * Willing to be randomized to either condition * have a Smartphone Exclusion Criteria: * Currently pregnant, nursing, or planning to become pregnant during the trial * Class III+ obesity * Diagnosed with lifetime or current Psychosis, Mania, or Bipolar Disorder, via the SCID * Diagnosed with current Substance Use Disorder, via the SCID * Active suicidal ideation with specific plan and intent ('5' score on Suicidal Ideation from Columbia Suicide Severity Rating Scale), which would necessitate immediate emergent care * Exhibit behavioral disturbance (e.g., aggression, mild-moderate cognitive impairment) that would significantly interfere with study participation, as assessed by clinical research personnel * Currently meets resistance exercise recommendations (2 days per week) for the last 8 weeks * Self-reporting a concussion/traumatic brain injury within the last 3 months * Having cardiovascular disease, uncontrolled hypertension, or uncontrolled diabetes
Contact & Investigator
Jacob Meyer, PhD
PRINCIPAL INVESTIGATOR
University of Wisconsin, Madison
Frequently Asked Questions
Who can join the NCT06110897 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Major Depressive Disorder. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06110897 currently recruiting?
Yes, NCT06110897 is actively recruiting participants. Contact the research team at jouzi@wisc.edu for enrollment information.
Where is the NCT06110897 trial being conducted?
This trial is being conducted at Ames, United States, Madison, United States.
Who is sponsoring the NCT06110897 clinical trial?
NCT06110897 is sponsored by University of Wisconsin, Madison. The principal investigator is Jacob Meyer, PhD at University of Wisconsin, Madison. The trial plans to enroll 200 participants.