NCT06094088 Researching Heat and Yoga for Mood Enhancement
| NCT ID | NCT06094088 |
| Status | Recruiting |
| Phase | — |
| Sponsor | Massachusetts General Hospital |
| Condition | Depression |
| Study Type | INTERVENTIONAL |
| Enrollment | 120 participants |
| Start Date | 2025-07-01 |
| Primary Completion | 2026-09-01 |
Eligibility & Interventions
Eligibility Fast-Check
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What to Expect as a Participant
You will actively receive the study intervention — which may be a drug, biologic, device, or procedure.
This trial targets 120 participants in total. It began in 2025-07-01 with a primary completion date of 2026-09-01.
⚠ This information is for research awareness only. Always consult your physician before joining any clinical trial. Participation is voluntary and you may withdraw at any time.
Brief Summary
This study will examine how doing heated yoga or non-heated yoga affects depression.
Eligibility Criteria
Inclusion Criteria: 1. adults (18-65 years old) 2. able to provide consent 3. are able to read and understand English 4. PHQ-9 score between 10-20, indicating moderate but not severe depressive symptom severity (27) 5. Must have filled out the waiver for the community-based yoga studio prior to enrolling in the study. Exclusion Criteria: 1. have had a bone fracture or joint surgery in the past 6 months 2. not able to walk freely or without difficulty 3. have severe heart failure or lung disease 4. participants endorse an item on the revised Physical Activity Readiness Questionnaire (PAR-Q+) and do not have approval from their treating physician (we will check in with treating physician in the event that participants endorse any item on the PAR-Q+) 5. participants must have a physician responsible for their medical care 6. are pregnant or planning to become pregnant 7. no more than 6 yoga classes in the past 6 months 8. have active suicidal thinking (i.e., PHQ-9 item 9 ≥1 and a positive response to C-SSRS screener items 3, 4, 5, or 6) 9. report manic symptoms (Altman Self-Rating Mania Scale score ≥ 6 (28)) 10. are on medications that make dehydration more likely (e.g., lithium, antipsychotics, insulin-dependent) 11. active eating disorders or substance use disorders within the past 12 months 12. antidepressant or psychiatric medications that are initiated less than 8 weeks or a dose change less than 4 weeks prior to screening visit 13. psychotherapy that has been initiated within the past 3 months 14. willingness to keep psychiatric medications and psychotherapy stable throughout the course of the study 15. psychiatric hospitalization within the past year 16. diagnosed with any neurological disorders that would impact participation or make participation unsafe 17. are currently in any active ketamine, ECT, or TMS 18. are unable to follow the study procedures (e.g., not able to travel to the heated or non-heated yoga studios)
Contact & Investigator
Frequently Asked Questions
Who can join the NCT06094088 clinical trial?
This trial is open to participants of all sexes, aged 18 Years or older, up to 65 Years, studying Depression. Full inclusion and exclusion criteria are listed in the Eligibility Criteria section. Always confirm your eligibility with the research team before applying.
Is NCT06094088 currently recruiting?
Yes, NCT06094088 is actively recruiting participants. Contact the research team at mnyer@mgh.harvard.edu for enrollment information.
Where is the NCT06094088 trial being conducted?
This trial is being conducted at Cambridge, United States, Cambridge, United States.
Who is sponsoring the NCT06094088 clinical trial?
NCT06094088 is sponsored by Massachusetts General Hospital. The trial plans to enroll 120 participants.
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