Trial Parameters
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Brief Summary
The goal of this clinical trial is to examine the effect of limb occlusion therapy (remote ischemic conditioning, RIC) in subjects with aneurysmal subarachnoid hemorrhage. The main question it aims to answer is whether RIC can improve long-term recovery in participants with aneurysmal subarachnoid hemorrhage. Researchers will compare levels of functional independence in participants in the RIC-group to participants in the sham-group.
Eligibility Criteria
Inclusion Criteria: * Aneurysmal subarachnoid hemorrhage confirmed by computed tomography (CT) with aneurysm origin confirmed by computed tomography angiography (CTA) or digital subtraction angiography (DSA) * Aneurysmal subarachnoid hemorrhage symptom-onset ≤ 3 days * Aneurysm protected by clipping or coiling * Independent in daily living before symptom onset (mRS ≤ 2) Exclusion Criteria: * Subarachnoid hemorrhage caused by a lesion other than cerebral aneurysm * Symptomatic vasospasm at the time of enrollment * Previous cerebral lesion e.g. symptomatic cerebral infarction (\>2cm), multiple sclerosis, symptomatic intracerebral hemorrhage, tumour, prior neurosurgery (excluding prior clipping or coiling of cold aneurysms without complications). * History of severe peripheral vascular disease or signs of severe peripheral vascular disease on physical examination * History of deep vein thrombosis or signs of deep vein thrombosis on physical examination * Kidney involvement or prior kidney